Patient P-03378
Therapy response
Declining
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
75%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S10
- Day 100 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 100.
Primary contributors, last 14 days
- GI instability+29
- Inflammatory activity+18
- Nutritional resilience-12
- Toxicity+12
- Treatment adherence-2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
64%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 85% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log3.1/10
worsening · -1.2 vs previous 14 d
Stress level
Daily log6/10
worsening · +1.4 vs previous 14 d
Pessimism score
Daily log5/10
worsening · +0.7 vs previous 14 d
Sleep quality
Wearable20.4/100
worsening · -7.2 vs previous 14 d
Libido
Daily log3.6/10
worsening · -0.8 vs previous 14 d
HRV
Wearable34.9 ms
worsening · -8.7 vs previous 14 d
Toxicity
Blood38.2/100
worsening · +11.8 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 41 from the failing basin, 51 from restoration.
Would help
- GI-04 GI Support Protocol85% improved among 27 similar · onset 8 d · confidence 62%
- DT-01 Dosing / Timing Recommendation85% improved among 13 similar · onset 5 d · confidence 78%
- HY-01 Hydration Protocol67% improved among 9 similar · onset 4 d · confidence 78%
- More proteinGI -7 next day on high-intake days · n 19
Would not help
- AD-05 Adherence Supportonly 25% improved among 8 similar
- Keep lactose lowGI +6.2 next day on high-intake days · n 22
- Keep histamine lowGI +5.9 next day on high-intake days · n 23
- Keep fat lowGI +5.2 next day on high-intake days · n 23
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-7supporter · 95%
- Lactose+6.2detractor · 95%
- Histamine load+5.9detractor · 95%
- Dietary fat load+5.2detractor · 95%
- Alcohol+1.5no signal · 25%
- Caffeine-0.2no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 55 and rising
- WearableSleep 5.3 h, below personal baseline
- Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 52
- WearableHRV 35 ms, trending down
- Autonomic recovery ↓45
- WearableResting HR 77 bpm
- WearableShort sleep window
- Butyrate / short-chain fatty acid production ↓35
- MicrobiomeButyrate capacity 31/100
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.6 · butyrate capacity 31/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 40 ms
- Sleep
- 5.7 h
- Steps
- 7,138
- Resting HR
- 74 bpm
Daily log: GI score 55, nutritional resilience 51, adherence 92.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03346 | 40% | S17 | GI-04 | improved | 71 |
| P-03379 | 38% | S12 | GI-04 | improved | 51 |
| P-03255 | 34% | S01 | HY-01 | improved | 53 |
| P-03382 | 33% | S01 | GI-04 | improved | 56 |
| P-03484 | 33% | S07 | DT-01 | improved | 49 |
| P-03031 | 32% | S16 | CR-01 | improved | 49 |
| P-03178 | 32% | S11 | GI-04 | improved | 54 |
| P-03374 | 32% | S19 | ME-01 | improved | 55 |
| P-03110 | 31% | S15 | GI-04 | improved | 52 |
| P-03179 | 31% | S05 | GI-04 | improved | 52 |
| P-03225 | 31% | S19 | GI-04 | improved | 50 |
| P-03252 | 31% | S13 | SC-12 | improved | 68 |