Patient P-03484
Therapy response
Stable
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
32%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S07
- Day 15 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 18 DT-01 recommended — Dosing / Timing Recommendation DT-01
- Day 19 Patient accepted — Started DT-01 in the companion
- Day 24 GI symptom burden −19% vs expected — Dosing / Timing Recommendation DT-01
- Day 30 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 15.
Primary contributors, last 14 days
- Nutritional resilience-15
- Inflammatory activity+13
- Toxicity+12
- GI instability+9
What helped?
- Dosing / Timing Recommendation DT-01Day 18Result: symptom burden −19%
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients.
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 24/100
- MicrobiomeF. prausnitzii depleted
- Autonomic recovery ↓45
- WearableResting HR 78 bpm
- WearableShort sleep window
- Inflammatory signalling ↑35
- MicrobiomeBacteroides fragilis expansion
- WearableHRV 32 ms, trending down
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
- Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 3 · butyrate capacity 24/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 28 ms
- Sleep
- 5.8 h
- Steps
- 6,414
- Resting HR
- 76 bpm
Daily log: GI score 32, nutritional resilience 53, adherence 96.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03198 | 52% | S11 | — | — | 52 |
| P-03420 | 50% | S08 | — | — | 59 |
| P-03389 | 49% | S01 | — | — | 50 |
| P-03255 | 48% | S01 | HY-01 | improved | 53 |
| P-03471 | 48% | S08 | — | — | 54 |
| P-03179 | 46% | S05 | GI-04 | improved | 52 |
| P-03102 | 45% | S19 | — | — | 35 |
| P-03144 | 45% | S16 | HY-01 | improved | 52 |
| P-03172 | 44% | S17 | DT-01 | no change | 48 |
| P-03372 | 44% | S19 | — | — | 53 |
| P-03219 | 43% | S17 | — | — | 49 |
| P-03064 | 42% | S10 | — | — | 50 |