Patient P-03392
Therapy response
Declining
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
25%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S15
- Day 15 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 18 GI-04 recommended — GI Support Protocol GI-04
- Day 19 Patient accepted — Started GI-04 in the companion
- Day 27 GI symptom burden −24% vs expected — GI Support Protocol GI-04
- Day 33 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 15.
Primary contributors, last 14 days
- Treatment adherence-11
- Nutritional resilience-9
- GI instability+8
- Inflammatory activity+8
- Toxicity+5
What helped?
- GI Support Protocol GI-04Day 18Result: symptom burden −24%
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients.
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Autonomic recovery ↓45
- WearableResting HR 74 bpm
- Wearable3,270 steps/day
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Rapid metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.6 · butyrate capacity 45/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 68 ms
- Sleep
- 7.9 h
- Steps
- 4,362
- Resting HR
- 74 bpm
Daily log: GI score 25, nutritional resilience 60, adherence 89.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03268 | 61% | S15 | DT-01 | improved | 56 |
| P-03339 | 52% | S19 | — | — | 49 |
| P-03408 | 47% | S09 | HY-01 | improved | 53 |
| P-03442 | 47% | S11 | DT-01 | improved | 51 |
| P-03143 | 46% | S11 | DT-01 | improved | 49 |
| P-03062 | 45% | S11 | — | — | 44 |
| P-03193 | 45% | S13 | DT-01 | improved | 53 |
| P-03244 | 45% | S08 | DT-01 | improved | 53 |
| P-03114 | 44% | S11 | DT-01 | improved | 48 |
| P-03167 | 44% | S18 | — | — | 53 |
| P-03375 | 43% | S09 | DT-01 | improved | 52 |
| P-03362 | 42% | S20 | — | — | 42 |