Patient P-03411
Therapy response
Improving
Tolerance
Favorable
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
47%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S07
- Day 90 BR-03 recommended — Behavioural Recommendation BR-03
- Day 91 Patient declined — Not now
- Day 104 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 104.
Primary contributors, last 14 days
- GI instability+20
- Inflammatory activity+17
- Nutritional resilience-14
What helped?
- Behavioural Recommendation BR-03Day 90Declined by patient
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients.
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
- Autonomic recovery ↓25
- WearableResting HR 76 bpm
- Inflammatory signalling ↑20
- MicrobiomeBacteroides fragilis expansion
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 4.4 · butyrate capacity 80/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 45 ms
- Sleep
- 6.9 h
- Steps
- 6,062
- Resting HR
- 74 bpm
Daily log: GI score 33, nutritional resilience 58, adherence 83.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03343 | 50% | S12 | — | — | 45 |
| P-03277 | 48% | S14 | BR-03 | improved | 41 |
| P-03139 | 44% | S13 | — | — | 42 |
| P-03202 | 44% | S14 | — | — | 44 |
| P-03424 | 43% | S12 | AD-05 | improved | 41 |
| P-03111 | 42% | S07 | AD-05 | no change | 48 |
| P-03197 | 42% | S14 | — | — | 41 |
| P-03204 | 41% | S16 | AD-05 | improved | 48 |
| P-03274 | 41% | S08 | — | — | 40 |
| P-03014 | 40% | S01 | — | — | 32 |
| P-03149 | 40% | S20 | — | — | 37 |
| P-03155 | 39% | S14 | — | — | 56 |