Patient P-03437
Therapy response
Unstable
Tolerance
Favorable
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
59%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S12
- Day 31 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 31.
Primary contributors, last 14 days
- GI instability+29
- Inflammatory activity+17
- Nutritional resilience-15
- Treatment adherence-5
- Toxicity-2
What helped?
No interventions yet.
LIFE OS recommendation
Dosing / Timing Recommendation DT-01
60%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 79% showed improvement
- median effect visible after 5 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log4.1/10
worsening · -0.4 vs previous 14 d
Stress level
Daily log3.3/10
worsening · +0.7 vs previous 14 d
Pessimism score
Daily log4.6/10
worsening · +0.5 vs previous 14 d
Sleep quality
Wearable29.3/100
worsening · -6.4 vs previous 14 d
Libido
Daily log4.9/10
worsening · -0.4 vs previous 14 d
HRV
Wearable67.3 ms
stable · -1.7 vs previous 14 d
Toxicity
Blood4.8/100
improving · -0.9 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 44 from the failing basin, 53 from restoration.
Would help
- DT-01 Dosing / Timing Recommendation79% improved among 14 similar · onset 5 d · confidence 61%
- HY-01 Hydration Protocol60% improved among 10 similar · onset 4 d · confidence 61%
- ME-01 Monitoring Escalation100% improved among 5 similar · onset 3 d · confidence 61%
- More proteinGI -4.6 next day on high-intake days · n 21
Would not help
- AD-05 Adherence Supportonly 31% improved among 13 similar
- Keep histamine lowGI +5.2 next day on high-intake days · n 26
- Keep lactose lowGI +4.5 next day on high-intake days · n 20
- Keep alcohol lowGI +3.1 next day on high-intake days · n 21
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+5.2detractor · 95%
- Protein-4.6supporter · 95%
- Lactose+4.5detractor · 95%
- Alcohol+3.1detractor · 81%
- Dietary fat load+0.5no signal · 15%
- Caffeine0no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↑45
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- Mucosal barrier integrity ↓40
- DNAFUT2 non-secretor lowers mucosal fucosylation
- WearableSleep 5.3 h, below personal baseline
- Autonomic recovery ↑40
- Wearable2,556 steps/day
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 4.4 · butyrate capacity 54/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 66 ms
- Sleep
- 6.3 h
- Steps
- 2,738
- Resting HR
- 64 bpm
Daily log: GI score 39, nutritional resilience 58, adherence 78.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Keep fibre steady; no new sources this week
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.