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Patient P-03437

Synthetic patientONX-7 · Day 139 · 45–54 · F · baseline S12Steering view · 3DOpen companion preview
Therapy response
Unstable
Tolerance
Favorable
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
59%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 ONX-7 started — Baseline state S12
  2. Day 31 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 31.

Primary contributors, last 14 days
  • GI instability+29
  • Inflammatory activity+17
  • Nutritional resilience-15
  • Treatment adherence-5
  • Toxicity-2

What helped?

No interventions yet.

    LIFE OS recommendation
    Dosing / Timing Recommendation DT-01
    60%
    probability of meaningful tolerance improvement
    • 284 similar trajectories
    • 79% showed improvement
    • median effect visible after 5 days
    View similar patientsSimulateAdd to intervention cohortAll evidence

    Daily trackers

    Molecule settings

    The trackers this program marks as important, last 14 days vs the 14 before.

    Energy level
    Daily log
    4.1/10
    worsening · -0.4 vs previous 14 d
    Stress level
    Daily log
    3.3/10
    worsening · +0.7 vs previous 14 d
    Pessimism score
    Daily log
    4.6/10
    worsening · +0.5 vs previous 14 d
    Sleep quality
    Wearable
    29.3/100
    worsening · -6.4 vs previous 14 d
    Libido
    Daily log
    4.9/10
    worsening · -0.4 vs previous 14 d
    HRV
    Wearable
    67.3 ms
    stable · -1.7 vs previous 14 d
    Toxicity
    Blood
    4.8/100
    improving · -0.9 vs previous 14 d
    This trajectory is decaying — what would help, what would not
    Steering view →

    Heading towards failing · 44 from the failing basin, 53 from restoration.

    Would help
    • DT-01 Dosing / Timing Recommendation
      79% improved among 14 similar · onset 5 d · confidence 61%
    • HY-01 Hydration Protocol
      60% improved among 10 similar · onset 4 d · confidence 61%
    • ME-01 Monitoring Escalation
      100% improved among 5 similar · onset 3 d · confidence 61%
    • More protein
      GI -4.6 next day on high-intake days · n 21
    Would not help
    • AD-05 Adherence Support
      only 31% improved among 13 similar
    • Keep histamine low
      GI +5.2 next day on high-intake days · n 26
    • Keep lactose low
      GI +4.5 next day on high-intake days · n 20
    • Keep alcohol low
      GI +3.1 next day on high-intake days · n 21
    State influencers · digestive

    Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

    • Histamine load
      +5.2detractor · 95%
    • Protein
      -4.6supporter · 95%
    • Lactose
      +4.5detractor · 95%
    • Alcohol
      +3.1detractor · 81%
    • Dietary fat load
      +0.5no signal · 15%
    • Caffeine
      0no signal · 15%

    Biological layers

    Which pathways look influenced, and by which layer of this person's biology.

    Pathways under pressure
    • Inflammatory signalling ↑45
      • DNAIL6 -174 variant raises baseline inflammatory tone
      • MicrobiomeBacteroides fragilis expansion
    • Mucosal barrier integrity ↓40
      • DNAFUT2 non-secretor lowers mucosal fucosylation
      • WearableSleep 5.3 h, below personal baseline
    • Autonomic recovery ↑40
      • Wearable2,556 steps/day
      • WearableShort sleep window
    DNA
    Fictional pharmacogenomic panel
    • FUT2 rs601338 AA (non-secretor)
      Reduced mucosal fucosylation
    • IL6 -174 G/C
      Higher inflammatory tone
    • CYP2D6 Rapid metabolizer
      Expected exposure
    Microbiome
    Shannon diversity 4.4 · butyrate capacity 54/100
    • Akkermansia muciniphilaNormal
    • Faecalibacterium prausnitziiNormal
    • Bacteroides fragilisHigh
    • Bifidobacterium longumLow
    • EnterobacteriaceaeHigh
    Wearable, last 14 days
    daily evolution fed into the runtime
    HRV
    66 ms
    Sleep
    6.3 h
    Steps
    2,738
    Resting HR
    64 bpm
    Daily log: GI score 39, nutritional resilience 58, adherence 78.

    What this patient sees in NostraAI

    The content that steers the trajectory: what to eat, what to do, what to take.

    Open companion preview
    What to eat
    • Keep meals regular; three to four moderate portions spaced through the day
    • Include a cooked vegetable portion with each main meal
    • Keep fibre steady; no new sources this week
    • Avoid known triggers for now: fried or oily food, dairy, alcohol
    What to do
    • Log the daily check-in; one line is enough
    • A 15-minute walk after lunch
    • Protect a 7.5-hour sleep window; screens off 30 minutes before
    • Keep hydration steady: small amounts through the day rather than large volumes at once
    What to take
    • Take the scheduled dose as agreed with your care team
    • No additional supplements this week
    • Fictional demo item: continue vitamin D as before

    284 biologically similar trajectories

    Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

    Sort by similaritySort by interventionSort by outcomeSort by stateSort by response
    PatientSimilarityBaselineInterventionOutcomeResponse today
    P-0310436%S14AD-05no change27
    P-0303433%S14AD-05no change30
    P-0315832%S17AD-05no change37
    P-0342432%S12AD-05improved41
    P-0336930%S18AD-05no change37
    P-0312229%S13AD-05no change40
    P-0338029%S16AD-05improved34
    P-0312928%S18AD-05no change32
    P-0320428%S16AD-05improved48
    P-0311127%S07AD-05no change48
    P-0310526%S12AD-05no change60
    P-0335125%S07AD-05no change51