Patient P-03460
Therapy response
Improving
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
88%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S11
- Day 56 SC-12 recommended — Supportive Compound SC-12
- Day 57 Patient accepted — Started SC-12 in the companion
- Day 63 GI symptom burden −18% vs expected — Supportive Compound SC-12
- Day 64 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 69 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 64.
Primary contributors, last 14 days
- Toxicity+13
- Nutritional resilience-9
- Treatment adherence-6
- GI instability+3
- Inflammatory activity+2
What helped?
- Supportive Compound SC-12Day 56Result: symptom burden −18%
LIFE OS recommendation
GI Support Protocol GI-04
91%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 82% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log2.3/10
improving · +0.5 vs previous 14 d
Stress level
Daily log7.4/10
improving · -0.7 vs previous 14 d
Pessimism score
Daily log5.9/10
improving · -0.8 vs previous 14 d
Sleep quality
Wearable19.5/100
worsening · -3.2 vs previous 14 d
Libido
Daily log2.1/10
improving · +0.6 vs previous 14 d
HRV
Wearable44.8 ms
improving · +4.8 vs previous 14 d
Toxicity
Blood54/100
improving · -9.3 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 24 from the failing basin, 67 from restoration.
Would help
- GI-04 GI Support Protocol73% improved among 33 similar · onset 8 d · confidence 96%
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 79%
- NP-02 Dietary Support Protocol57% improved among 14 similar · onset 10 d · confidence 79%
- More proteinGI -4.6 next day on high-intake days · n 20
Would not help
- AD-05 Adherence Supportonly 17% improved among 12 similar
- Keep fat lowGI +4.2 next day on high-intake days · n 20
- Keep histamine lowGI +3.2 next day on high-intake days · n 20
- Keep lactose lowGI +3.2 next day on high-intake days · n 20
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-4.6supporter · 95%
- Dietary fat load+4.2detractor · 95%
- Histamine load+3.2detractor · 95%
- Lactose+3.2detractor · 89%
- Alcohol+1.8no signal · 45%
- Caffeine+0.3no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 31/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 63 and rising
- WearableSleep 5.2 h, below personal baseline
- Inflammatory signalling ↑45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 60
- Drug metabolism and exposure ↑20
- BloodToxicity index 54
- Autonomic recovery ↓20
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 3.1 · butyrate capacity 31/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 53 ms
- Sleep
- 5.8 h
- Steps
- 6,320
- Resting HR
- 67 bpm
Daily log: GI score 63, nutritional resilience 33, adherence 48.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03037 | 47% | S14 | NP-02 | improved | 43 |
| P-03323 | 46% | S14 | GI-04 | improved | 48 |
| P-03293 | 43% | S14 | GI-04 | no change | 41 |
| P-03430 | 42% | S14 | SC-12 | improved | 45 |
| P-03049 | 41% | S14 | GI-04 | improved | 49 |
| P-03345 | 41% | S14 | SC-12 | improved | 56 |
| P-03413 | 41% | S14 | ME-01 | improved | 48 |
| P-03341 | 39% | S14 | NP-02 | improved | 49 |
| P-03081 | 37% | S10 | GI-04 | improved | 53 |
| P-03390 | 37% | S14 | ME-01 | improved | 41 |
| P-03090 | 36% | S02 | GI-04 | improved | 48 |
| P-03030 | 35% | S14 | NP-02 | improved | 43 |