NP-02 · Dietary Support Protocol
Nutritional protocolSynthetic demo dataTarget state: Nutritional decline · onset 10 d · prior: symptom −28%, persistence +9%, tolerance +12%Simulate for P-02005
For P-02005
Eligible at 54% confidence. Among the 284 most similar trajectories: 6 accepted, 67% improved, mean effect −15%.
What it is
A dietitian-designed 21-day nutrition protocol delivered daily in the companion: personalized meal structure, protein targets, and removal of the foods this patient's own log shows as detractors.
How it works
Reduces the dietary loads that precede GI rises for this patient (fat, histamine, simple carbs, lactose — whichever the attribution shows), stabilises nutritional state and appetite, and restores fibre gradually for butyrate producers.
What the patient does, day by day
| Day 1 | ✓ | Attribution read The companion shows which foods preceded GI rises in the last 60 days. |
| Every day | 🍽 | Protein-forward breakfast ≥ 25 g protein within 2 h of waking. |
| Every day | 🍽 | Remove top detractors The two dietary loads with the largest next-day GI effect for this patient. |
| Every day | 🍽 | Daily fermented food Kefir / yoghurt, or sauerkraut for lactose intolerance. |
| Week 2+ | 🍽 | Fibre ramp Soluble fibre +5 g per week on non-dosing days. |
| Weekly | 🏥 | Dietitian review Log review, protein and weight check. |
Delivery
- Owner
- Companion
- Channel
- Daily meal guidance in the companion; dietitian reviews weekly
- Duration
- 21 days
- Touchpoints
- Morning meal plan; evening food log
- Cost
- ≈ €150 per patient (dietitian time)
Monitoring
- · Food log completeness
- · Weight weekly
- · Daily GI
- · Nutritional state
Stop rules
- · Weight −3 % → dietitian call
- · GI ≥ 60 for 3 days → switch to GI-04
Contraindications
- · Enteral / parenteral nutrition
- · Severe dysphagia
Evidence in META-24
41 accepted · 59% improved · mean effect −14%By biology segment
| FUT2 non-secretor | n 26 | 73% |
| Baseline state S14 | n 25 | 68% |
| IL6 high-expression variant | n 26 | 65% |
| Cluster EC-03 (high response / high intolerance) | n 36 | 64% |
| Poor metabolizer | n 8 | 63% |
| Adherence < 60% | n 30 | 60% |
| Low microbial diversity | n 31 | 55% |
| Low butyrate capacity | n 26 | 46% |
By trajectory cluster
| EC-03 | n 36 | 64% |
Works best when
- · Clear dietary detractors in the log
- · Low microbial diversity
- · Nutritional decline is the leading state
Works poorly when
- · Poor metabolizers (toxicity-led)
- · Adherence < 60 %
- · No food logging
What the model has learned about it
No learned rule yet for NP-02. Run learning after campaign results.
Campaigns using it
None yet. 158 patients look eligible right now.