The side-effect ledger: incidence now vs the first two weeks, what reduced each one (and for which biology), what made it worse, and the honest residual — patients where nothing found works yet.

Which side effects, and how do we minimize them?

Synthetic demo data

GI burden ≥ 50 · Companion

first 2 weeks 6% → now 14% (96 patients)

Reduced by

DT-01 94% of 16
HY-01 86% of 14
best in Poor metabolizer 100%
GI-04 75% of 28
best in IL6 high-expression variant 85%

Made worse by

fat (96%)
ultra-processed (84%)
simple carbs (73%)

Residual · unsolved

1 patients with the pattern and no untried action that improved ≥ 55% of similar cases. This is the number to work on.

Toxicity ≥ 50 · Blood

first 2 weeks 0% → now 8% (59 patients)

Reduced by

DT-01 86% of 7

Made worse by

fat (95%)
ultra-processed (83%)
simple carbs (76%)

Residual · unsolved

0 patients with the pattern and no untried action that improved ≥ 55% of similar cases. This is the number to work on.

Fatigue (energy < 4) · Daily log

first 2 weeks 0% → now 15% (107 patients)

Reduced by

DT-01 94% of 16
HY-01 86% of 14
best in Poor metabolizer 100%
GI-04 76% of 25
best in IL6 high-expression variant 90%

Made worse by

fat (96%)
ultra-processed (86%)
simple carbs (75%)

Residual · unsolved

4 patients with the pattern and no untried action that improved ≥ 55% of similar cases. This is the number to work on.

Low mood (pessimism > 7) · Daily log

first 2 weeks 9% → now 1% (10 patients)

Reduced by

DT-01 91% of 11
HY-01 89% of 9
best in Poor metabolizer 100%
GI-04 60% of 5

Made worse by

poor-sleep weeks
low-HRV stretches
fat (90%)

Residual · unsolved

0 patients with the pattern and no untried action that improved ≥ 55% of similar cases. This is the number to work on.

Poor sleep (quality < 40) · Wearable

first 2 weeks 13% → now 33% (234 patients)

Reduced by

DT-01 94% of 16
HY-01 80% of 15
best in Low microbial diversity 100%
SC-12 73% of 15
best in Adherence < 60% 90%

Made worse by

poor-sleep weeks
low-HRV stretches
fat (66%)

Residual · unsolved

62%

144 patients with the pattern and no untried action that improved ≥ 55% of similar cases. This is the number to work on.

Glucose > 140 (CGM) · CGM

first 2 weeks 0% → now 17% (122 patients)

Reduced by

HY-01 92% of 12
best in Poor metabolizer 100%
DT-01 88% of 17
best in IL6 high-expression variant 100%
SC-12 75% of 8
best in Adherence < 60% 100%

Made worse by

fat (81%)
ultra-processed (80%)
simple carbs (69%)

Residual · unsolved

24%

29 patients with the pattern and no untried action that improved ≥ 55% of similar cases. This is the number to work on.