DeepGene damage signature

SyntheticSynthetic demo data2 samples: baseline day 0 · retest day 90

Damage score · retest day 90

84/100

vs baseline (day 0)

+10

1 improved · 8 worsened

synthetic signature · consistent with this patient's biology

3 opportunists above range: Escherichia coli, Streptococcus gallolyticus, Clostridioides difficile
5 keystone species absent
Shannon 2.27 (expected ≥ 3)
9 resistance genes
Host DNA fragmentation atypical
Tissue recycling index 56

Pathogens / opportunists3/5

↓ from 4

Keystone species5/8

↑ from 4

Diversity2/2

Metabolic modules1/4

Vitamin synthesis4/7

↑ from 3

Oral translocation1/1

Host DNA1/1

↑ from 0

Tissue recycling1/1

Central mechanisms2/2

↑ from 1

Virulence factors5/5

↑ from 4

Antibiotic resistance genes9/9

↑ from 6

Genetic predisposition2/2

Opportunists above range

Escherichia coli 25.768% AR

Streptococcus gallolyticus 2.577% AR

Clostridioides difficile 2.577% AR

Keystone species absent

Akkermansia muciniphila, Bifidobacterium longum, Butyricicoccus pullicaecorum, Eubacterium rectale, Faecalibacterium prausnitzii

Capacity

Shannon 2.27 · butyrate 414 CPM · SCFA 806

H2S above band

4 vitamins below

Host & mechanisms

host DNA fragmentation atypical

tissue recycling 56/100

oral translocation 5.85% AR

molecular_mimicry above

estrobolome above

9 resistance genes · 5 virulence factors

Import a sample

day Import DeepGene CSV

A baseline sample re-initializes this patient's microbiome, pathways and predispositions from the measurement; a retest adds a comparison and updates them. Every theory, steering gain and dietary sensitivity downstream is then conditioned on the measured signature.

All elements · baseline → latest

Value, status vs the expected range, and the implication on health. Changes coloured: green improved / resolved, red worsened / new.

Pathogens / opportunists · 5

Escherichia coli	20.444 % AR · above range	25.768 % AR · above range	expected <= 1%	In excess raises LPS load and zonulin release, opening tight junctions.
Klebsiella pneumoniae	0.014 % AR · in range	0.194 % AR · in range	expected <= 0.3%	Opportunist above range; relevant after antibiotics and in inflammation.
Enterococcus faecium	10.222 % AR · above range	0.222 % AR · in range(improved)	expected <= 0.5%	Opportunist above range; relevant after antibiotics and in inflammation.
Streptococcus gallolyticus	2.044 % AR · above range	2.577 % AR · above range	expected <= 0.1%	Opportunist above range; relevant after antibiotics and in inflammation.
Clostridioides difficile	2.044 % AR · above range	2.577 % AR · above range	expected <= 0.1%	Opportunist above range; relevant after antibiotics and in inflammation.

Keystone species · 8

Akkermansia muciniphila	0 % AR · absent	0 % AR · absent	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Bifidobacterium longum	0 % AR · absent	0 % AR · absent	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Butyricicoccus pullicaecorum	0 % AR · absent	0 % AR · absent	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Eubacterium rectale	0 % AR · absent	0 % AR · absent	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Faecalibacterium prausnitzii	1.32 % AR · in range	0 % AR · absent(worsened)	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Lactobacillus species	0.34 % AR · in range	0.63 % AR · in range	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Roseburia intestinalis	1.31 % AR · in range	1.29 % AR · in range	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Ruminococcus bromii	0.26 % AR · in range	0.36 % AR · in range	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.

Diversity · 2

indice Shannon	2.45 · below range	2.27 · below range	expected >= 3.0	Low diversity: fewer reserve metabolic routes, slower recovery after perturbation.
numar de specii detectate	98 specii · below range	88 specii · below range	expected >= 100	Species count below reference.

Metabolic modules · 4

Butyrate production	537 CPM · in range	414 CPM · in range	expected 255.83-1089.91 CPM	Butyrate is the main colonocyte fuel and barrier signal.
Short Chain Fatty Acid Production	898 CPM · in range	806 CPM · in range	expected 535.03-1572.59 CPM	Total SCFA capacity.
GABA production	311 CPM · in range	244 CPM · in range	expected 87.31-766.53 CPM	Gut–brain axis capacity.
H2S production (sulfate reduction)	465 CPM · above range	479 CPM · above range	expected banda de referinta	Hydrogen sulfide above band irritates the mucosa.

Vitamin synthesis · 7

Vitamin B1 - Thiamin	176 CPM · below range	537 CPM · below range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B2 - Riboflavin	165 CPM · below range	341 CPM · below range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B5 - Pantothenic acid	282 CPM · below range	251 CPM · below range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B6 - Pyridoxine	2755 CPM · in range	321 CPM · below range(worsened)	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B7 - Biotin	2838 CPM · in range	3905 CPM · in range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B9 - Folate	3365 CPM · in range	3631 CPM · in range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B12 - Cobalamin	4316 CPM · in range	3796 CPM · in range	expected 2000-5000 CPM	Microbial synthesis capacity.

Oral translocation · 1

Translocare orala (indice)

4.65 % AR · above range

5.85 % AR · above range

expected <= 2%

Oral taxa in stool: reduced gastric barrier or dysbiosis.

Host DNA · 1

fragmentare mixta

156 pb · in range

247 pb · atypical(worsened)

expected 150-170 pb

Host cell-free DNA fragmentation pattern.

Tissue recycling · 1

indice de reciclare tisulara

48 /100 · above range

56 /100 · above range

expected < 35

Epithelial turnover.

Central mechanisms · 2

molecular_mimicry	70 /100 · above range	68 /100 · above range	expected < 65	Cross-reactive antigen load.
estrobolome	64 /100 · in range	67 /100 · above range(worsened)	expected < 65	Estrogen-recycling capacity.

Virulence factors · 5

fimD outer membrane usher	21 potriviri/M · present	43 potriviri/M · present	expected absent	Virulence factor detected.
chuA heme/hemoglobin receptor	46 potriviri/M · present	43 potriviri/M · present	expected absent	Virulence factor detected.
irp2 yersiniabactin synthetase	34 potriviri/M · present	92 potriviri/M · present	expected absent	Virulence factor detected.
espX4 type III secretion	46 potriviri/M · present	91 potriviri/M · present	expected absent	Virulence factor detected.
kpsD polysialic acid transport	—	77 potriviri/M · present(new)	expected absent	Virulence factor detected.

Antibiotic resistance genes · 9

sul1	1.1 citiri/M · present	4.4 citiri/M · present	expected nedetectat	Resistance gene detected.
sul2	8.7 citiri/M · present	8 citiri/M · present	expected nedetectat	Resistance gene detected.
tet(O/M/O)	5.1 citiri/M · present	1.9 citiri/M · present	expected nedetectat	Resistance gene detected.
Ecol_ampC_BLA	1.3 citiri/M · present	9.6 citiri/M · present	expected nedetectat	Resistance gene detected.
aadA	10.9 citiri/M · present	8.9 citiri/M · present	expected nedetectat	Resistance gene detected.
dfrA1	2.9 citiri/M · present	1.1 citiri/M · present	expected nedetectat	Resistance gene detected.
APH(6)-Id	—	3.8 citiri/M · present(new)	expected nedetectat	Resistance gene detected.
Erm(49)	—	10.4 citiri/M · present(new)	expected nedetectat	Resistance gene detected.
msrC	—	8 citiri/M · present(new)	expected nedetectat	Resistance gene detected.

Genetic predisposition · 2

FUT2	2.65 OR · risk variant	2.74 OR · risk variant	expected reference genotype	Reduced mucosal fucosylation
CYP2D6	2.39 OR · risk variant	1.94 OR · risk variant	expected reference genotype	Expected exposure