Patient P-02046

Synthetic patientMETA-24 · Day 161 · 45–54 · F · baseline S10Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Unstable

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

61%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S10
Day 122 CR-01 recommended — Clinician Review CR-01
Day 123 Patient declined — Not now
Day 127 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 127.

Primary contributors, last 14 days

Nutritional resilience-11
Treatment adherence-9
Toxicity+6

What helped?

Clinician Review CR-01Day 122
Declined by patient

LIFE OS recommendation

GI Support Protocol GI-04

61%

probability of meaningful tolerance improvement

284 similar trajectories
88% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

9 min

stable · +0.2 vs previous 14 d

Sleep duration

Wearable

5.7 h

stable · +0.1 vs previous 14 d

Energy level

Daily log

2.8/10

stable · +0.0 vs previous 14 d

Steps

Wearable

1,871

improving · +130 vs previous 14 d

GI burden

Companion

60.8/100

stable · -1.9 vs previous 14 d

Adherence

Companion

62.9 %

worsening · -10.3 vs previous 14 d

Sleep quality

Wearable

14.3/100

improving · +3.1 vs previous 14 d

Glucose, CGM daily mean

CGM

145 mg/dL

stable · -0.9 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 32 from the failing basin, 64 from restoration.

Would help

GI-04 GI Support Protocol
75% improved among 65 similar · onset 8 d · confidence 56%
ME-01 Monitoring Escalation
100% improved among 42 similar · onset 3 d · confidence 62%
NP-02 Dietary Support Protocol
59% improved among 32 similar · onset 10 d · confidence 62%
More protein
GI -4.3 next day on high-intake days · n 18

Would not help

Keep caffeine low
GI +4.9 next day on high-intake days · n 22
Keep simple carbs low
GI +4 next day on high-intake days · n 21
Keep histamine low
GI +3.9 next day on high-intake days · n 24

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Caffeine
+4.9detractor · 95%
Protein
-4.3supporter · 95%
Simple carbohydrates
+4detractor · 95%
Histamine load
+3.9detractor · 95%
Ultra-processed food
+3.6detractor · 78%
Insoluble fibre
+0.6no signal · 15%
Dietary fat load
-0.3no signal · 15%
Alcohol
+0.1no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 61 and rising
- WearableSleep 5.7 h, below personal baseline
Autonomic recovery ↓65
- WearableResting HR 86 bpm
- Wearable1,871 steps/day
- WearableShort sleep window
Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 59
Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↓40
- BloodInflammatory load index 63
- WearableHRV 24 ms, trending down

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Poor metabolizer
Higher exposure at standard dose
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.3 · butyrate capacity 46/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 31 ms
Sleep: 5.6 h
Steps: 966
Resting HR: 87 bpm

Daily log: GI score 61, nutritional resilience 31, adherence 63.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02151	49%	S04	CR-01	improved	49
P-02025	40%	S15	CR-01	improved	61
P-02094	40%	S14	NP-02	improved	53
P-02165	39%	S14	ME-01	improved	59
P-02433	39%	S07	GI-04	improved	61
P-02334	38%	S04	GI-04	improved	66
P-02508	38%	S14	ME-01	improved	51
P-02054	37%	S01	CR-01	improved	57
P-02236	37%	S14	GI-04	improved	45
P-02348	36%	S14	GI-04	improved	49
P-02648	36%	S14	SC-12	improved	47
P-02009	35%	S08	CR-01	improved	64