Patient P-02130
Therapy response
Declining
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
29%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S20
- Day 15 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 22 GI-04 recommended — GI Support Protocol GI-04
- Day 23 Patient declined — Not now
What changed?
Trajectory began diverging from predicted response on Day 15.
Primary contributors, last 14 days
- GI instability+13
- Inflammatory activity+13
- Toxicity+13
- Nutritional resilience-11
- Treatment adherence+4
What helped?
- GI Support Protocol GI-04Day 22Declined by patient
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients.
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
- Butyrate / short-chain fatty acid production ↓35
- MicrobiomeButyrate capacity 30/100
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
- Inflammatory signalling ↑20
- MicrobiomeBacteroides fragilis expansion
DNA
Fictional pharmacogenomic panel
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 3 · butyrate capacity 30/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 52 ms
- Sleep
- 6.9 h
- Steps
- 3,846
- Resting HR
- 70 bpm
Daily log: GI score 24, nutritional resilience 58, adherence 97.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02303 | 52% | S15 | GI-04 | improved | 48 |
| P-02616 | 49% | S06 | — | — | 51 |
| P-02645 | 49% | S02 | HY-01 | improved | 56 |
| P-02045 | 48% | S07 | — | — | 52 |
| P-02235 | 48% | S14 | DT-01 | improved | 50 |
| P-02312 | 48% | S20 | — | — | 54 |
| P-02394 | 48% | S12 | — | — | 62 |
| P-02573 | 48% | S10 | — | — | 52 |
| P-02602 | 48% | S20 | HY-01 | improved | 52 |
| P-02697 | 48% | S07 | GI-04 | improved | 56 |
| P-02169 | 47% | S17 | — | — | 43 |
| P-02033 | 46% | S06 | GI-04 | improved | 51 |