Patient P-02303
Therapy response
Declining
Tolerance
Favorable
GI state
Deteriorating
Inflammatory state
Favorable
Nutritional resilience
Favorable
Discontinuation risk
18%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S15
- Day 13 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 22 GI-04 recommended — GI Support Protocol GI-04
- Day 23 Patient accepted — Started GI-04 in the companion
- Day 31 GI symptom burden −21% vs expected — GI Support Protocol GI-04
- Day 37 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 13.
Primary contributors, last 14 days
- GI instability+5
- Inflammatory activity+3
- Toxicity+2
What helped?
- GI Support Protocol GI-04Day 22Result: symptom burden −21%
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients.
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 32/100
- MicrobiomeF. prausnitzii depleted
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
- Inflammatory signalling ↑25
- DNAIL6 -174 variant raises baseline inflammatory tone
DNA
Fictional pharmacogenomic panel
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Intermediate metabolizerExpected exposure
Microbiome
Shannon diversity 2.3 · butyrate capacity 32/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 54 ms
- Sleep
- 8.0 h
- Steps
- 7,482
- Resting HR
- 62 bpm
Daily log: GI score 19, nutritional resilience 67, adherence 96.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02494 | 55% | S09 | GI-04 | improved | 47 |
| P-02169 | 54% | S17 | — | — | 43 |
| P-02235 | 53% | S14 | DT-01 | improved | 50 |
| P-02573 | 53% | S10 | — | — | 52 |
| P-02665 | 53% | S15 | — | — | 56 |
| P-02130 | 52% | S20 | — | — | 49 |
| P-02070 | 51% | S11 | — | — | 55 |
| P-02105 | 51% | S08 | — | — | 54 |
| P-02295 | 51% | S04 | — | — | 50 |
| P-02645 | 51% | S02 | HY-01 | improved | 56 |
| P-02685 | 51% | S16 | DT-01 | improved | 47 |
| P-02147 | 50% | S13 | GI-04 | improved | 58 |