Patient P-02131

Synthetic patientMETA-24 · Day 168 · 25–34 · F · baseline S20Steering view · 3D Open companion preview

Therapy response

Unstable

Tolerance

Improving

GI state

Deteriorating

Inflammatory state

Improving

Nutritional resilience

Favorable

Discontinuation risk

24%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S20
Day 43 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 43.

Primary contributors, last 14 days

Toxicity-12
Inflammatory activity-11
Treatment adherence-9
GI instability+4

What helped?

No interventions yet.

LIFE OS recommendation

No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

74 min

stable · -2.9 vs previous 14 d

Sleep duration

Wearable

6.9 h

stable · -0.1 vs previous 14 d

Energy level

Daily log

5.6/10

stable · -0.1 vs previous 14 d

Steps

Wearable

8,717

stable · +29 vs previous 14 d

GI burden

Companion

24.5/100

worsening · +4.4 vs previous 14 d

Adherence

Companion

79.5 %

stable · +2.3 vs previous 14 d

Sleep quality

Wearable

60.3/100

worsening · -3.0 vs previous 14 d

Glucose, CGM daily mean

CGM

122 mg/dL

stable · +0.9 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 64 from the failing basin, 50 from restoration.

Good elements to keep

Butyrate producers intact
hidden · steering +7.5
Protein (supports)
perturbation · steering +4.8
Protein
supporter · GI -2.5 next day

Main detractors to watch

FUT2 non-secretor
hidden · steering -10.6
Low microbial diversity
hidden · steering -7.7
Bacteroides fragilis elevated
hidden · steering -7.4
IL6 high-expression variant
hidden · steering -7.3
Histamine load
detractor · GI +2.7 next day
Ultra-processed food
detractor · GI +2.5 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+2.7detractor · 95%
Ultra-processed food
+2.5detractor · 95%
Protein
-2.5supporter · 95%
Simple carbohydrates
+1.2no signal · 51%
Dietary fat load
+0.3no signal · 15%
Insoluble fibre
-0.3no signal · 15%
Caffeine
-0.1no signal · 15%
Alcohol
0no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↓45
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
Autonomic recovery ↑25
- WearableResting HR 75 bpm

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure
GLP1R rs6923761 A
Altered receptor sensitivity

Microbiome

Shannon diversity 2.8 · butyrate capacity 57/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 68 ms
Sleep: 6.9 h
Steps: 8,984
Resting HR: 75 bpm

Daily log: GI score 25, nutritional resilience 63, adherence 80.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Keep fibre steady; no new sources this week
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02016	44%	S20	DT-01	improved	27
P-02331	37%	S14	BR-03	improved	34
P-02479	33%	S13	DT-01	improved	48
P-02484	33%	S15	GI-04	improved	49
P-02564	32%	S15	BR-03	improved	32
P-02031	31%	S12	AD-05	improved	47
P-02494	31%	S09	GI-04	improved	47
P-02685	31%	S16	DT-01	improved	47
P-02223	30%	S20	HY-01	improved	49
P-02339	30%	S03	DT-01	improved	50
P-02033	29%	S06	GI-04	improved	51
P-02167	29%	S02	HY-01	improved	54