Patient P-02234

Synthetic patientMETA-24 · Day 154 · 55–64 · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Unstable

Tolerance

Deteriorating

GI state

Stable

Inflammatory state

Stable

Nutritional resilience

Unstable

Discontinuation risk

72%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S14
Day 47 NP-02 recommended — Dietary Support Protocol NP-02
Day 48 Patient accepted — Started NP-02 in the companion
Day 58 GI symptom burden −11% vs expected — Dietary Support Protocol NP-02
Day 64 Tolerance state changed — Unstable → Improving
Day 77 GI-04 recommended — GI Support Protocol GI-04
Day 78 Patient accepted — Started GI-04 in the companion
Day 85 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 86 GI symptom burden −21% vs expected — GI Support Protocol GI-04
Day 92 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 85.

Primary contributors, last 14 days

Toxicity+8
Nutritional resilience+5
GI instability-2
Inflammatory activity+2

What helped?

Dietary Support Protocol NP-02Day 47
Result: symptom burden −11%
GI Support Protocol GI-04Day 77
Result: symptom burden −21%

LIFE OS recommendation

Monitoring Escalation ME-01

83%

probability of meaningful tolerance improvement

284 similar trajectories
100% showed improvement
median effect visible after 3 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

64 min

worsening · -2.8 vs previous 14 d

Sleep duration

Wearable

7.2 h

worsening · -0.4 vs previous 14 d

Energy level

Daily log

2.6/10

worsening · -0.6 vs previous 14 d

Steps

Wearable

6,052

stable · -54 vs previous 14 d

GI burden

Companion

54.4/100

worsening · +7.7 vs previous 14 d

Adherence

Companion

46.9 %

stable · +0.1 vs previous 14 d

Sleep quality

Wearable

48.4/100

worsening · -10.3 vs previous 14 d

Glucose, CGM daily mean

CGM

140 mg/dL

stable · +4.3 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 22 from the failing basin, 65 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 42 similar · onset 3 d · confidence 71%
SC-12 Supportive Compound
69% improved among 26 similar · onset 6 d · confidence 71%
CR-01 Clinician Review
100% improved among 6 similar · onset 5 d · confidence 71%
More protein
GI -5.7 next day on high-intake days · n 22

Would not help

Keep fat low
GI +5.8 next day on high-intake days · n 30
Keep ultra-processed low
GI +5.3 next day on high-intake days · n 22
Keep simple carbs low
GI +4.6 next day on high-intake days · n 17

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+5.8detractor · 95%
Protein
-5.7supporter · 95%
Ultra-processed food
+5.3detractor · 95%
Simple carbohydrates
+4.6detractor · 95%
Alcohol
+4detractor · 90%
Insoluble fibre
+3.2detractor · 61%
Caffeine
+1.3no signal · 25%
Histamine load
-0.8no signal · 16%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 33/100
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↑50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 56
Autonomic recovery ↓25
- WearableResting HR 80 bpm
Mucosal barrier integrity ↓20
- Daily logGI symptom score 54 and rising
Drug metabolism and exposure ↑20
- BloodToxicity index 54

DNA

Fictional pharmacogenomic panel

IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure
GLP1R rs6923761 A
Altered receptor sensitivity
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2 · butyrate capacity 33/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 53 ms
Sleep: 7.0 h
Steps: 6,861
Resting HR: 80 bpm

Daily log: GI score 54, nutritional resilience 42, adherence 47.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02093	20%	S05	AD-05	no change	40
P-02285	20%	S14	AD-05	no change	39
P-02483	22%	S06	BR-03	no change	64
P-02087	21%	S01	BR-03	no change	40
P-02308	20%	S13	BR-03	no change	27
P-02054	31%	S01	CR-01	improved	57
P-02151	31%	S04	CR-01	improved	49
P-02154	31%	S16	CR-01	improved	57
P-02009	30%	S08	CR-01	improved	64
P-02025	30%	S15	CR-01	improved	61
P-02233	27%	S16	CR-01	improved	66
P-02395	22%	S12	DT-01	improved	57