Patient P-02241

Synthetic patientMETA-24 · Day 176 · 35–44 · F · baseline S09Steering view · 3D Open companion preview

Therapy response

Improving

Tolerance

Stable

GI state

Improving

Inflammatory state

Stable

Nutritional resilience

Improving

Discontinuation risk

56%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S09
Day 66 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 77 GI-04 recommended — GI Support Protocol GI-04
Day 78 Patient accepted — Started GI-04 in the companion
Day 79 ME-01 recommended — Monitoring Escalation ME-01
Day 80 Patient accepted — Started ME-01 in the companion
Day 83 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
Day 86 GI symptom burden −40% vs expected — GI Support Protocol GI-04
Day 92 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 66.

Primary contributors, last 14 days

Treatment adherence-6
GI instability-5
Nutritional resilience+5
Inflammatory activity+3

What helped?

GI Support Protocol GI-04Day 77
Result: symptom burden −40%
Monitoring Escalation ME-01Day 79
Result: deterioration detected before clinical escalation

LIFE OS recommendation

Dietary Support Protocol NP-02

54%

probability of meaningful tolerance improvement

284 similar trajectories
64% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

64 min

stable · -1.4 vs previous 14 d

Sleep duration

Wearable

7.3 h

improving · +0.3 vs previous 14 d

Energy level

Daily log

4.1/10

improving · +0.2 vs previous 14 d

Steps

Wearable

7,246

improving · +344 vs previous 14 d

GI burden

Companion

49/100

stable · -0.5 vs previous 14 d

Adherence

Companion

44.2 %

worsening · -2.3 vs previous 14 d

Sleep quality

Wearable

36.3/100

improving · +4.4 vs previous 14 d

Glucose, CGM daily mean

CGM

132 mg/dL

stable · +0.8 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 40 from the failing basin, 48 from restoration.

Good elements to keep

GI Support Protocol GI-04
intervention · steering +53.9
Protein (supports)
perturbation · steering +6.7
Monitoring Escalation ME-01
intervention · steering +4.1
Protein
supporter · GI -4 next day

Main detractors to watch

Low butyrate capacity
hidden · steering -17.5
Poor metabolizer
hidden · steering -12.7
FUT2 non-secretor
hidden · steering -10.6
Dietary fat load
perturbation · steering -8.6
Caffeine
detractor · GI +4.2 next day
Dietary fat load
detractor · GI +4.1 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Caffeine
+4.2detractor · 95%
Dietary fat load
+4.1detractor · 95%
Protein
-4supporter · 95%
Histamine load
+3.7detractor · 95%
Ultra-processed food
-0.6no signal · 15%
Alcohol
-0.5no signal · 15%
Simple carbohydrates
-0.3no signal · 15%
Insoluble fibre
+0.3no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 49 and rising
Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 22/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↑60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 52
- WearableHRV 28 ms, trending down
Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 44
Autonomic recovery ↑25
- WearableResting HR 76 bpm

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Poor metabolizer
Higher exposure at standard dose

Microbiome

Shannon diversity 3 · butyrate capacity 22/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 33 ms
Sleep: 7.1 h
Steps: 5,722
Resting HR: 74 bpm

Daily log: GI score 49, nutritional resilience 46, adherence 44.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02018	45%	S01	GI-04	improved	46
P-02410	42%	S01	GI-04	improved	55
P-02054	36%	S01	CR-01	improved	57
P-02409	34%	S01	SC-12	no change	54
P-02307	24%	S01	—	—	55
P-02598	24%	S01	—	—	53
P-02550	23%	S01	—	—	70
P-02276	22%	S01	—	—	57
P-02437	22%	S01	—	—	64
P-02568	22%	S01	—	—	51
P-02041	21%	S01	—	—	27
P-02087	21%	S01	BR-03	no change	40