Patient P-02274
Therapy response
Stable
Tolerance
Deteriorating
GI state
Improving
Inflammatory state
Favorable
Nutritional resilience
Favorable
Discontinuation risk
17%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S15
- Day 14 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 22 DT-01 recommended — Dosing / Timing Recommendation DT-01
- Day 23 Patient accepted — Started DT-01 in the companion
- Day 28 GI symptom burden −22% vs expected — Dosing / Timing Recommendation DT-01
- Day 34 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 14.
Primary contributors, last 14 days
- GI instability-10
- Toxicity+8
- Inflammatory activity+4
- Nutritional resilience-3
- Treatment adherence-2
What helped?
- Dosing / Timing Recommendation DT-01Day 22Result: symptom burden −22%
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Active minutes
Wearable31 min
worsening · -3.1 vs previous 14 d
Sleep duration
Wearable5.6 h
stable · +0.0 vs previous 14 d
Energy level
Daily log5.3/10
stable · +0.2 vs previous 14 d
Steps
Wearable4,163
worsening · -306 vs previous 14 d
GI burden
Companion21.5/100
worsening · +4.0 vs previous 14 d
Adherence
Companion93.7 %
stable · -3.0 vs previous 14 d
Sleep quality
Wearable24.5/100
stable · +0.0 vs previous 14 d
Glucose, CGM daily mean
CGM139 mg/dL
stable · +1.7 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 63 from the failing basin, 31 from restoration.
Would help
- No untried action with strong evidence. Compose one from primitives.
- More proteinGI -3.7 next day on high-intake days · n 18
Would not help
- Keep histamine lowGI +3.9 next day on high-intake days · n 20
- Keep fat lowGI +3.8 next day on high-intake days · n 18
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+3.9detractor · 95%
- Dietary fat load+3.8detractor · 95%
- Protein-3.7supporter · 95%
- Insoluble fibre+1no signal · 29%
- Caffeine+0.8no signal · 22%
- Simple carbohydrates+0.4no signal · 15%
- Alcohol-0.4no signal · 15%
- Ultra-processed food0no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓70
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- WearableSleep 5.6 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓35
- MicrobiomeButyrate capacity 30/100
- Inflammatory signalling ↑20
- MicrobiomeBacteroides fragilis expansion
- Autonomic recovery ↑20
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 3 · butyrate capacity 30/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 41 ms
- Sleep
- 6.4 h
- Steps
- 4,254
- Resting HR
- 68 bpm
Daily log: GI score 22, nutritional resilience 61, adherence 94.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.