Patient P-02326

Synthetic patientMETA-24 · Day 171 · 35–44 · M · baseline S18Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Deteriorating

GI state

Unstable

Inflammatory state

Stable

Nutritional resilience

Unstable

Discontinuation risk

90%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S18
Day 47 NP-02 recommended — Dietary Support Protocol NP-02
Day 48 Patient accepted — Started NP-02 in the companion
Day 58 GI symptom burden −18% vs expected — Dietary Support Protocol NP-02
Day 64 Tolerance state changed — Unstable → Improving
Day 70 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 72 SC-12 recommended — Supportive Compound SC-12
Day 73 Patient accepted — Started SC-12 in the companion
Day 78 GI-04 recommended — GI Support Protocol GI-04
Day 79 Patient declined — Not now
Day 79 GI symptom burden −14% vs expected — Supportive Compound SC-12
Day 85 Tolerance state changed — Unstable → Improving
Day 89 ME-01 recommended — Monitoring Escalation ME-01
Day 90 Patient accepted — Started ME-01 in the companion
Day 93 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 70.

Primary contributors, last 14 days

Toxicity+14
Treatment adherence-9
Nutritional resilience-6
GI instability+4
Inflammatory activity+3

What helped?

Dietary Support Protocol NP-02Day 47
Result: symptom burden −18%
Supportive Compound SC-12Day 72
Result: symptom burden −14%
GI Support Protocol GI-04Day 78
Declined by patient
Monitoring Escalation ME-01Day 89
Result: deterioration detected before clinical escalation

LIFE OS recommendation

GI Support Protocol GI-04

87%

probability of meaningful tolerance improvement

284 similar trajectories
88% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

44 min

worsening · -3.3 vs previous 14 d

Sleep duration

Wearable

6.2 h

improving · +0.2 vs previous 14 d

Energy level

Daily log

2.1/10

improving · +0.5 vs previous 14 d

Steps

Wearable

4,616

worsening · -274 vs previous 14 d

GI burden

Companion

59.2/100

improving · -2.6 vs previous 14 d

Adherence

Companion

40 %

worsening · -5.5 vs previous 14 d

Sleep quality

Wearable

39/100

improving · +4.0 vs previous 14 d

Glucose, CGM daily mean

CGM

138 mg/dL

stable · -3.4 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 25 from the failing basin, 64 from restoration.

Would help

GI-04 GI Support Protocol
75% improved among 65 similar · onset 8 d · confidence 86%
CR-01 Clinician Review
100% improved among 6 similar · onset 5 d · confidence 71%
DT-01 Dosing / Timing Recommendation
67% improved among 6 similar · onset 5 d · confidence 71%
More protein
GI -6.8 next day on high-intake days · n 19

Would not help

Keep fat low
GI +6.9 next day on high-intake days · n 25
Keep ultra-processed low
GI +6.2 next day on high-intake days · n 26
Keep simple carbs low
GI +5.5 next day on high-intake days · n 22

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+6.9detractor · 95%
Protein
-6.8supporter · 95%
Ultra-processed food
+6.2detractor · 95%
Simple carbohydrates
+5.5detractor · 95%
Histamine load
+5.1detractor · 95%
Insoluble fibre
-0.5no signal · 15%
Alcohol
+0.5no signal · 15%
Caffeine
+0.4no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 39/100
- Daily logFibre intake low in recent food logs
Mucosal barrier integrity ↓50
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 59 and rising
Inflammatory signalling ↑50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 57
Autonomic recovery ↓45
- WearableResting HR 74 bpm
- WearableShort sleep window
Drug metabolism and exposure ↑20
- BloodToxicity index 55

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Intermediate metabolizer
Expected exposure

Microbiome

Shannon diversity 1.9 · butyrate capacity 39/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 49 ms
Sleep: 6.1 h
Steps: 3,602
Resting HR: 75 bpm

Daily log: GI score 59, nutritional resilience 38, adherence 40.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02670	51%	S14	SC-12	improved	45
P-02018	50%	S01	GI-04	improved	46
P-02234	50%	S14	GI-04	improved	36
P-02253	50%	S14	NP-02	no change	41
P-02559	50%	S18	SC-12	no change	48
P-02059	49%	S03	SC-12	improved	41
P-02316	49%	S14	GI-04	improved	51
P-02516	49%	S14	SC-12	improved	51
P-02535	49%	S14	SC-12	improved	50
P-02106	48%	S14	GI-04	improved	44
P-02348	48%	S14	GI-04	improved	49
P-02401	47%	S14	GI-04	improved	49