Patient P-02460

Synthetic patientMETA-24 · Day 110 · 55–64 · F · baseline S18Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Favorable

GI state

Stable

Inflammatory state

Improving

Nutritional resilience

Stable

Discontinuation risk

50%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S18
Day 72 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 74 GI-04 recommended — GI Support Protocol GI-04
Day 75 Patient accepted — Started GI-04 in the companion
Day 83 GI symptom burden −33% vs expected — GI Support Protocol GI-04
Day 89 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 72.

Primary contributors, last 14 days

Treatment adherence-28
Inflammatory activity-7
Nutritional resilience+4
GI instability-3
Toxicity-3

What helped?

GI Support Protocol GI-04Day 74
Result: symptom burden −33%

LIFE OS recommendation

Dietary Support Protocol NP-02

53%

probability of meaningful tolerance improvement

284 similar trajectories
73% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

54 min

improving · +4.9 vs previous 14 d

Sleep duration

Wearable

8 h

stable · +0.0 vs previous 14 d

Energy level

Daily log

4.2/10

worsening · -0.6 vs previous 14 d

Steps

Wearable

6,269

improving · +437 vs previous 14 d

GI burden

Companion

52.3/100

stable · +0.9 vs previous 14 d

Adherence

Companion

58.9 %

worsening · -16.8 vs previous 14 d

Sleep quality

Wearable

56.1/100

stable · -1.0 vs previous 14 d

Glucose, CGM daily mean

CGM

134 mg/dL

stable · -3.0 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 44 from the failing basin, 46 from restoration.

Would help

NP-02 Dietary Support Protocol
62% improved among 29 similar · onset 10 d · confidence 56%
DT-01 Dosing / Timing Recommendation
80% improved among 5 similar · onset 5 d · confidence 56%
More protein
GI -3.2 next day on high-intake days · n 18

Would not help

Keep histamine low
GI +3.2 next day on high-intake days · n 21
Keep fat low
GI +2.7 next day on high-intake days · n 23

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+3.2detractor · 95%
Protein
-3.2supporter · 95%
Dietary fat load
+2.7detractor · 95%
Caffeine
+1.3no signal · 39%
Simple carbohydrates
+1no signal · 24%
Insoluble fibre
-0.5no signal · 15%
Ultra-processed food
-0.3no signal · 15%
Alcohol
-0.1no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 52 and rising
Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 28/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↓45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 47

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure
GLP1R rs6923761 A
Altered receptor sensitivity

Microbiome

Shannon diversity 3.1 · butyrate capacity 28/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 56 ms
Sleep: 7.2 h
Steps: 5,828
Resting HR: 65 bpm

Daily log: GI score 52, nutritional resilience 47, adherence 59.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02409	32%	S01	SC-12	no change	54
P-02410	32%	S01	GI-04	improved	55
P-02054	31%	S01	CR-01	improved	57
P-02018	29%	S01	GI-04	improved	46
P-02217	25%	S01	—	—	61
P-02276	25%	S01	—	—	57
P-02307	25%	S01	—	—	55
P-02437	25%	S01	—	—	64
P-02550	25%	S01	—	—	70
P-02598	25%	S01	—	—	53
P-02138	24%	S01	—	—	79
P-02681	24%	S01	—	—	51