Patient P-02479

Synthetic patientMETA-24 · Day 161 · 45–54 · F · baseline S13Open companion preview

Therapy response

Stable

Tolerance

Favorable

GI state

Improving

Inflammatory state

Improving

Nutritional resilience

Improving

Discontinuation risk

11%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S13
Day 15 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 22 DT-01 recommended — Dosing / Timing Recommendation DT-01
Day 23 Patient accepted — Started DT-01 in the companion
Day 28 GI symptom burden −14% vs expected — Dosing / Timing Recommendation DT-01
Day 34 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 15.

Primary contributors, last 14 days

GI instability-21
Inflammatory activity-14
Nutritional resilience+7
Treatment adherence+3

What helped?

Dosing / Timing Recommendation DT-01Day 22
Result: symptom burden −14%

LIFE OS recommendation

No intervention is indicated right now. The trajectory is stable relative to similar patients.

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 37/100
- MicrobiomeF. prausnitzii depleted
Mucosal barrier integrity ↓40
- MicrobiomeAkkermansia low → thinner mucus layer
- WearableSleep 6.1 h, below personal baseline
Autonomic recovery ↑20
- WearableShort sleep window

DNA

Fictional pharmacogenomic panel

CYP2D6 Rapid metabolizer
Expected exposure

Microbiome

Shannon diversity 2.5 · butyrate capacity 37/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 62 ms
Sleep: 6.0 h
Steps: 9,367
Resting HR: 58 bpm

Daily log: GI score 22, nutritional resilience 66, adherence 95.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02147	50%	S13	GI-04	improved	58
P-02303	49%	S15	GI-04	improved	48
P-02494	49%	S09	GI-04	improved	47
P-02167	47%	S02	HY-01	improved	54
P-02602	46%	S20	HY-01	improved	52
P-02685	46%	S16	DT-01	improved	47
P-02484	45%	S15	GI-04	improved	49
P-02586	45%	S18	DT-01	improved	56
P-02645	45%	S02	HY-01	improved	56
P-02697	45%	S07	GI-04	improved	56
P-02218	44%	S01	DT-01	improved	61
P-02223	44%	S20	HY-01	improved	49