DeepGene damage signature
SyntheticSynthetic demo data2 samples: baseline day 0 · retest day 90
Damage score · retest day 90
91/100
vs baseline (day 0)
+17
2 improved · 17 worsened
synthetic signature · consistent with this patient's biology
- 4 opportunists above range: Escherichia coli, Klebsiella pneumoniae, Streptococcus gallolyticus
- 7 keystone species absent
- Shannon 1.34 (expected ≥ 3)
- Butyrate production 169 CPM, below range
- 12 resistance genes
- Host DNA fragmentation atypical
- Tissue recycling index 73
Pathogens / opportunists4/5
↑ from 3
Keystone species7/8
↑ from 4
Diversity2/2
Metabolic modules2/4
↑ from 0
Vitamin synthesis6/7
↑ from 4
Oral translocation1/1
Host DNA1/1
↑ from 0
Tissue recycling1/1
Central mechanisms2/2
Virulence factors7/7
↑ from 4
Antibiotic resistance genes12/12
↑ from 8
Genetic predisposition2/2
Opportunists above range
Escherichia coli 38.323% AR
Klebsiella pneumoniae 11.497% AR
Streptococcus gallolyticus 3.832% AR
Clostridioides difficile 3.832% AR
Keystone species absent
Akkermansia muciniphila, Bifidobacterium longum, Butyricicoccus pullicaecorum, Eubacterium rectale, Faecalibacterium prausnitzii
Capacity
Shannon 1.34 · butyrate 169 CPM · SCFA 422
6 vitamins below
Host & mechanisms
host DNA fragmentation atypical
tissue recycling 73/100
oral translocation 8.67% AR
molecular_mimicry above
estrobolome above
12 resistance genes · 7 virulence factors
Import a sample
A baseline sample re-initializes this patient's microbiome, pathways and predispositions from the measurement; a retest adds a comparison and updates them. Every theory, steering gain and dietary sensitivity downstream is then conditioned on the measured signature.
All elements · baseline → latest
Value, status vs the expected range, and the implication on health. Changes coloured: green improved / resolved, red worsened / new.
Pathogens / opportunists · 5
| Escherichia coli | 0.542 % AR · in range | 38.323 % AR · above range(worsened) | expected <= 1% | In excess raises LPS load and zonulin release, opening tight junctions. |
| Klebsiella pneumoniae | 7.3 % AR · above range | 11.497 % AR · above range | expected <= 0.3% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Enterococcus faecium | 12.167 % AR · above range | 0.076 % AR · in range(improved) | expected <= 0.5% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Streptococcus gallolyticus | 2.433 % AR · above range | 3.832 % AR · above range | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Clostridioides difficile | 0.039 % AR · in range | 3.832 % AR · above range(worsened) | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
Keystone species · 8
| Akkermansia muciniphila | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Bifidobacterium longum | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Butyricicoccus pullicaecorum | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Eubacterium rectale | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Faecalibacterium prausnitzii | 0.06 % AR · in range | 0 % AR · absent(worsened) | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Lactobacillus species | 0.42 % AR · in range | 0 % AR · absent(worsened) | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Roseburia intestinalis | 0.86 % AR · in range | 0 % AR · absent(worsened) | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Ruminococcus bromii | 1.4 % AR · in range | 1.16 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
Diversity · 2
| indice Shannon | 2.44 · below range | 1.34 · below range | expected >= 3.0 | Low diversity: fewer reserve metabolic routes, slower recovery after perturbation. |
| numar de specii detectate | 82 specii · below range | 39 specii · below range | expected >= 100 | Species count below reference. |
Metabolic modules · 4
| Butyrate production | 470 CPM · in range | 169 CPM · below range(worsened) | expected 255.83-1089.91 CPM | Butyrate is the main colonocyte fuel and barrier signal. |
| Short Chain Fatty Acid Production | 845 CPM · in range | 422 CPM · below range(worsened) | expected 535.03-1572.59 CPM | Total SCFA capacity. |
| GABA production | 244 CPM · in range | 90 CPM · in range | expected 87.31-766.53 CPM | Gut–brain axis capacity. |
| H2S production (sulfate reduction) | 98 CPM · in range | 89 CPM · in range | expected banda de referinta | Hydrogen sulfide above band irritates the mucosa. |
Vitamin synthesis · 7
| Vitamin B1 - Thiamin | 489 CPM · below range | 418 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B2 - Riboflavin | 440 CPM · below range | 275 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B5 - Pantothenic acid | 330 CPM · below range | 370 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B6 - Pyridoxine | 503 CPM · below range | 230 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B7 - Biotin | 2907 CPM · in range | 266 CPM · below range(worsened) | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B9 - Folate | 2638 CPM · in range | 409 CPM · below range(worsened) | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B12 - Cobalamin | 3809 CPM · in range | 3999 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
Oral translocation · 1
| Translocare orala (indice) | 5.53 % AR · above range | 8.67 % AR · above range | expected <= 2% | Oral taxa in stool: reduced gastric barrier or dysbiosis. |
Host DNA · 1
| fragmentare mixta | 159 pb · in range | 220 pb · atypical(worsened) | expected 150-170 pb | Host cell-free DNA fragmentation pattern. |
Tissue recycling · 1
| indice de reciclare tisulara | 46 /100 · above range | 73 /100 · above range | expected < 35 | Epithelial turnover. |
Central mechanisms · 2
| molecular_mimicry | 68 /100 · above range | 90 /100 · above range | expected < 65 | Cross-reactive antigen load. |
| estrobolome | 69 /100 · above range | 78 /100 · above range | expected < 65 | Estrogen-recycling capacity. |
Species dominance · 1
| Escherichia coli | 38.96 % AR · above range | resolved(resolved) | expected < 20% per specie | One species occupies the niche of others. |
Virulence factors · 7
| fimD outer membrane usher | 74 potriviri/M · present | 72 potriviri/M · present | expected absent | Virulence factor detected. |
| chuA heme/hemoglobin receptor | 100 potriviri/M · present | 77 potriviri/M · present | expected absent | Virulence factor detected. |
| irp2 yersiniabactin synthetase | 41 potriviri/M · present | 77 potriviri/M · present | expected absent | Virulence factor detected. |
| espX4 type III secretion | 25 potriviri/M · present | 43 potriviri/M · present | expected absent | Virulence factor detected. |
| kpsD polysialic acid transport | — | 60 potriviri/M · present(new) | expected absent | Virulence factor detected. |
| acrB acriflavine resistance | — | 62 potriviri/M · present(new) | expected absent | Virulence factor detected. |
| rhs/PAAR type VI secretion | — | 38 potriviri/M · present(new) | expected absent | Virulence factor detected. |
Antibiotic resistance genes · 12
| sul1 | 5 citiri/M · present | 3.3 citiri/M · present | expected nedetectat | Resistance gene detected. |
| sul2 | 10.6 citiri/M · present | 2.6 citiri/M · present | expected nedetectat | Resistance gene detected. |
| tet(O/M/O) | 5.8 citiri/M · present | 4.8 citiri/M · present | expected nedetectat | Resistance gene detected. |
| Ecol_ampC_BLA | 8.4 citiri/M · present | 9.2 citiri/M · present | expected nedetectat | Resistance gene detected. |
| aadA | 7.2 citiri/M · present | 4.3 citiri/M · present | expected nedetectat | Resistance gene detected. |
| dfrA1 | 2.8 citiri/M · present | 7.4 citiri/M · present | expected nedetectat | Resistance gene detected. |
| APH(6)-Id | 10 citiri/M · present | 4.1 citiri/M · present | expected nedetectat | Resistance gene detected. |
| Erm(49) | 6.3 citiri/M · present | 6.3 citiri/M · present | expected nedetectat | Resistance gene detected. |
| msrC | — | 5.4 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
| eptB | — | 5.5 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
| ugd | — | 6.1 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
| arnA | — | 1.6 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
Genetic predisposition · 2
| FUT2 | 3.37 OR · risk variant | 3.11 OR · risk variant | expected reference genotype | Reduced mucosal fucosylation |
| IL6 | 2.34 OR · risk variant | 1.93 OR · risk variant | expected reference genotype | Higher inflammatory tone |