Patient P-01332
Therapy response 45 at the day-84 endpoint (observed).
Responding: response probability 44%, therapy response 41 today; biology is not blocking the drug.
Drift detected on day 48 (trajectory left the model); the side effect would have been reported on day 57 — 9 days of warning.
7 of 8 scheduled doses in the last 60 days are biologically confirmed (88%); 1 were logged but show no dose signature. Dose signature: resting HR +5 bpm, HRV −10 ms.
100% of 284 similar trajectories improved after ME-01; if this one does, discontinuation risk is expected to fall from 67% to ~49%. Keeping fat low is worth 6.5 GI points a day on its own. Losing this patient costs €57k; the intervention costs €180.
- 🍽Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- 🍽Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- ✓Track each bowel movement today: time, stool form, urgency, overnight waking
- ✓Keep the current walking rhythm
- 💊Take the scheduled dose as agreed with your care team
- 💊Electrolyte solution, one sachet after any loose stool
Dose is being missed; nothing else works until this is fixed.
GI burden above 69 for 3 days within the onset window
P-01332 is on day 90 of NBL-101 (EC-03, baseline S14): response unstable, tolerance stable, GI unstable. Over 14 days response moved -14 and GI -2; discontinuation risk is 67%. The state is in the failing basin, heading towards failing, after diverging from the model on day 48.
Biology sets the gain: FUT2 non-secretor, IL6 high-expression variant, Poor metabolizer, Low butyrate capacity, Low microbial diversity, Baseline state S14, Cluster EC-03 (high response / high intolerance), Adherence < 60%; butyrate capacity 28/100, diversity 1.9. Pushing it down: Enterococcus faecium 16.88% (LPS load) (-28.5), Low butyrate capacity (-23.3), Dietary fat load (-20.5). Pulling it up: GI Support Protocol GI-04 (+28.4), Dietary Support Protocol NP-02 (+24.5). From the daily log: fat +6.5 GI next day, simple carbs +6 GI next day, histamine +5.2 GI next day.
Past actions: NP-02 on day 32 → improved (15%); GI-04 on day 54 → improved (22%).
Next: ME-01 — 100% of 284 similar trajectories improved, 83% probability here. This would be contradicted by a further GI rise within the onset window or falling adherence.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 NBL-101 started — Baseline state S14
- Day 31 NP-02 recommended — Dietary Support Protocol NP-02
- Day 32 Patient accepted — Started NP-02 in the companion
- Day 42 GI symptom burden −15% vs expected — Dietary Support Protocol NP-02
- Day 48 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 48 Tolerance state changed — Unstable → Improving
- Day 53 GI-04 recommended — GI Support Protocol GI-04
- Day 54 Patient accepted — Started GI-04 in the companion
- Day 62 GI symptom burden −22% vs expected — GI Support Protocol GI-04
- Day 68 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 48.
- Treatment adherence-3
- GI instability-2
- Toxicity+2
What helped?
- Dietary Support Protocol NP-02Day 31Result: symptom burden −15%
- GI Support Protocol GI-04Day 53Result: symptom burden −22%
- 284 similar trajectories
- 100% showed improvement
- median effect visible after 3 days
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards failing · 23 from the failing basin, 66 from restoration.
- Keep fat lowGI +6.5 next day on high-intake days · n 28
- Keep simple carbs lowGI +6 next day on high-intake days · n 26
- Keep histamine lowGI +5.2 next day on high-intake days · n 23
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+6.5detractor · 95%
- Simple carbohydrates+6detractor · 95%
- Histamine load+5.2detractor · 95%
- Spicy / capsaicin-2.6no signal · 43%
- Insoluble fibre+0.3no signal · 15%
- Alcohol+0.3no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 3 opportunists above range: Enterococcus faecium, Streptococcus gallolyticus, Clostridioides difficile
- 6 keystone species absent
- Shannon 1.64 (expected ≥ 3)
- 10 resistance genes
- Host DNA fragmentation atypical
- Tissue recycling index 60
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 61 and rising
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 28/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 56
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 41
- Autonomic recovery ↑25
- WearableResting HR 79 bpm
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
- HRV
- 45 ms
- Sleep
- 7.3 h
- Steps
- 7,014
- Resting HR
- 79 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01345 | 22% | S02 | AD-05 | improved | 36 |
| P-01650 | 23% | S14 | BR-03 | improved | 38 |
| P-01768 | 36% | S17 | CR-01 | improved | 58 |
| P-01877 | 35% | S01 | CR-01 | improved | 61 |
| P-01600 | 34% | S09 | CR-01 | improved | 58 |
| P-01514 | 32% | S13 | CR-01 | improved | 46 |
| P-01699 | 31% | S19 | CR-01 | improved | 55 |
| P-01708 | 30% | S14 | CR-01 | improved | 63 |
| P-01697 | 27% | S13 | CR-01 | improved | 56 |
| P-01725 | 24% | S01 | CR-01 | improved | 62 |
| P-01794 | 24% | S13 | CR-01 | improved | 51 |
| P-01585 | 24% | S17 | DT-01 | improved | 50 |