Patient P-01342

Synthetic patientNBL-101 · Day 111 · 65–74 · M · baseline S11Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Deteriorating

GI state

Favorable

Inflammatory state

Favorable

Nutritional resilience

Declining

Discontinuation risk

22%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S11
Day 11 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 14 DT-01 recommended — Dosing / Timing Recommendation DT-01
Day 15 Patient accepted — Started DT-01 in the companion
Day 20 GI symptom burden −14% vs expected — Dosing / Timing Recommendation DT-01
Day 26 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 11.

Primary contributors, last 14 days

Toxicity+13
Nutritional resilience-6
Inflammatory activity+3
GI instability+2

What helped?

Dosing / Timing Recommendation DT-01Day 14
Result: symptom burden −14%

LIFE OS recommendation

No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

29.4/100

stable · -0.5 vs previous 14 d

Toxicity

Blood

21.3/100

worsening · +3.7 vs previous 14 d

Sleep quality

Wearable

51.2/100

improving · +4.7 vs previous 14 d

Energy level

Daily log

4.9/10

stable · -0.2 vs previous 14 d

Stress level

Daily log

4.1/10

stable · -0.1 vs previous 14 d

Steps

Wearable

7,166

stable · +196 vs previous 14 d

Adherence

Companion

95.4 %

stable · +3.4 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 58 from the failing basin, 33 from restoration.

Would help

No untried action with strong evidence. Compose one from primitives.

Would not help

Keep fat low
GI +4.3 next day on high-intake days · n 18
Keep simple carbs low
GI +3.9 next day on high-intake days · n 21

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+4.3detractor · 95%
Simple carbohydrates
+3.9detractor · 95%
Spicy / capsaicin
-1.7no signal · 47%
Histamine load
-1.5no signal · 35%
Insoluble fibre
+0.3no signal · 15%
Alcohol
0no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 40/100
- MicrobiomeF. prausnitzii depleted
Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
Inflammatory signalling ↑20
- MicrobiomeBacteroides fragilis expansion

DNA

Fictional pharmacogenomic panel

DPYD *2A heterozygous
Slower drug clearance
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.8 · butyrate capacity 40/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 41 ms
Sleep: 7.8 h
Steps: 6,745
Resting HR: 59 bpm

Daily log: GI score 29, nutritional resilience 56, adherence 95.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01585	55%	S13	—	—	49
P-01871	51%	S16	HY-01	no change	57
P-01752	49%	S20	DT-01	improved	50
P-01346	48%	S12	DT-01	improved	52
P-01701	48%	S11	—	—	55
P-01787	48%	S19	—	—	51
P-01823	48%	S01	—	—	57
P-01487	47%	S03	—	—	48
P-01519	46%	S06	—	—	48
P-01562	46%	S04	HY-01	no change	49
P-01593	46%	S10	HY-01	improved	56
P-01818	46%	S15	—	—	46