Patient P-01464
Therapy response 69 at the day-84 endpoint (observed).
Responding: response probability 79%, therapy response 76 today; biology is not blocking the drug.
No side effect starting: gi toxicity 12, systemic toxicity 13, no drift from the model.
8 of 9 scheduled doses in the last 60 days are biologically confirmed (89%); 1 were logged but show no dose signature. Dose signature: resting HR +6 bpm, HRV −10 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓Keep the current walking rhythm
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-01464 is on day 116 of NBL-101 (SR, baseline S05): response declining, tolerance deteriorating, GI improving. Over 14 days response moved -9 and GI -6; discontinuation risk is 8%. The state is in the restoration basin, heading towards failing.
Butyrate capacity 64/100, diversity 3.5, normal metabolizer. Pushing it down: Escherichia coli 10.608% (LPS load) (-27.1), Bacteroides fragilis elevated (-11.9), Antibiotic course (-4.7). Pulling it up: Butyrate producers intact (+12.1), Daily walks resumed (+3.3).
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 NBL-101 started — Baseline state S05
What changed?
Trajectory is tracking the baseline prediction.
- Inflammatory activity+9
- GI instability-6
- Toxicity+5
- Nutritional resilience+2
- Treatment adherence+2
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards failing · 87 from the failing basin, 8 from restoration.
- No untried action with strong evidence. Compose one from primitives.
- Nothing clearly counter-productive in the record.
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Simple carbohydrates-2.3no signal · 36%
- Dietary fat load+1.8no signal · 43%
- Alcohol+1.7no signal · 35%
- Insoluble fibre+1.5no signal · 31%
- Spicy / capsaicin-0.8no signal · 15%
- Histamine load-0.7no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 3 opportunists above range: Escherichia coli, Klebsiella pneumoniae, Clostridioides difficile
- 2 keystone species absent
- Shannon 2.94 (expected ≥ 3)
- 4 resistance genes
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Autonomic recovery ↑45
- WearableResting HR 75 bpm
- WearableShort sleep window
- Mucosal barrier integrity ↓40
- MicrobiomeAkkermansia low → thinner mucus layer
- WearableSleep 5.8 h, below personal baseline
- Inflammatory signalling ↑20
- MicrobiomeBacteroides fragilis expansion
- CYP2D6 Normal metabolizerExpected exposure
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
- HRV
- 47 ms
- Sleep
- 6.1 h
- Steps
- 6,103
- Resting HR
- 74 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Keep fibre steady; no new sources this week
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.