Patient P-01574

Synthetic patientNBL-101 · Day 110 · 75+ · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Improving

GI state

Improving

Inflammatory state

Improving

Nutritional resilience

Stable

Discontinuation risk

51%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 31 NP-02 recommended — Dietary Support Protocol NP-02
Day 32 Patient accepted — Started NP-02 in the companion
Day 42 GI symptom burden −19% vs expected — Dietary Support Protocol NP-02
Day 48 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 48 Tolerance state changed — Unstable → Improving
Day 57 GI-04 recommended — GI Support Protocol GI-04
Day 58 Patient accepted — Started GI-04 in the companion
Day 66 GI symptom burden −32% vs expected — GI Support Protocol GI-04
Day 72 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 48.

Primary contributors, last 14 days

Inflammatory activity-11
Toxicity-8
GI instability-4

What helped?

Dietary Support Protocol NP-02Day 31
Result: symptom burden −19%
GI Support Protocol GI-04Day 57
Result: symptom burden −32%

LIFE OS recommendation

Monitoring Escalation ME-01

68%

probability of meaningful tolerance improvement

284 similar trajectories
100% showed improvement
median effect visible after 3 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

36.2/100

worsening · +4.1 vs previous 14 d

Toxicity

Blood

30.7/100

improving · -2.9 vs previous 14 d

Sleep quality

Wearable

39.5/100

stable · -0.7 vs previous 14 d

Energy level

Daily log

5.1/10

worsening · -0.2 vs previous 14 d

Stress level

Daily log

5.6/10

stable · -0.2 vs previous 14 d

Steps

Wearable

7,346

stable · +35 vs previous 14 d

Adherence

Companion

52.9 %

improving · +2.3 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 51 from the failing basin, 39 from restoration.

Good elements to keep

GI Support Protocol GI-04
intervention · steering +50.1
Dietary Support Protocol NP-02
intervention · steering +30.7
Daily walks resumed
perturbation · steering +3.3

Main detractors to watch

Low butyrate capacity
hidden · steering -17.5
Poor metabolizer
hidden · steering -12.7
FUT2 non-secretor
hidden · steering -10.6
Low microbial diversity
hidden · steering -7.7
Simple carbohydrates
detractor · GI +3.3 next day
Dietary fat load
detractor · GI +2.8 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Simple carbohydrates
+3.3detractor · 95%
Dietary fat load
+2.8detractor · 95%
Insoluble fibre
+2.2detractor · 73%
Histamine load
+2detractor · 77%
Alcohol
+1.4detractor · 55%
Spicy / capsaicin
+1no signal · 36%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 24/100
- MicrobiomeF. prausnitzii depleted
Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
Inflammatory signalling ↓35
- MicrobiomeBacteroides fragilis expansion
- WearableHRV 29 ms, trending down
Autonomic recovery ↑25
- WearableResting HR 74 bpm

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Poor metabolizer
Higher exposure at standard dose
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.3 · butyrate capacity 24/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 31 ms
Sleep: 6.4 h
Steps: 6,976
Resting HR: 75 bpm

Daily log: GI score 36, nutritional resilience 53, adherence 53.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01568	55%	S14	GI-04	improved	40
P-01534	54%	S14	GI-04	improved	50
P-01663	54%	S14	GI-04	improved	48
P-01323	53%	S14	GI-04	improved	50
P-01649	50%	S14	GI-04	improved	46
P-01518	47%	S14	GI-04	improved	40
P-01490	46%	S05	GI-04	improved	51
P-01678	46%	S14	GI-04	improved	44
P-01688	46%	S01	GI-04	improved	40
P-01383	45%	S14	NP-02	improved	40
P-01543	45%	S14	GI-04	improved	54
P-01473	44%	S14	GI-04	improved	51