Patient P-01656

Synthetic patientNBL-101 · Day 103 · 65–74 · M · baseline S14Steering view · 3D Open companion preview

Therapy response

Unstable

Tolerance

Stable

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

83%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 48 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 53 GI-04 recommended — GI Support Protocol GI-04
Day 54 Patient accepted — Started GI-04 in the companion
Day 62 No meaningful change — GI Support Protocol GI-04
Day 68 ME-01 recommended — Monitoring Escalation ME-01
Day 69 Patient accepted — Started ME-01 in the companion
Day 72 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 48.

Primary contributors, last 14 days

GI instability+7
Inflammatory activity+6
Nutritional resilience+2
Treatment adherence+2

What helped?

GI Support Protocol GI-04Day 53
Result: no meaningful change
Monitoring Escalation ME-01Day 68
Result: deterioration detected before clinical escalation

LIFE OS recommendation

Dietary Support Protocol NP-02

61%

probability of meaningful tolerance improvement

284 similar trajectories
66% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

65.8/100

improving · -2.9 vs previous 14 d

Toxicity

Blood

46.9/100

stable · +1.0 vs previous 14 d

Sleep quality

Wearable

33.9/100

worsening · -1.9 vs previous 14 d

Energy level

Daily log

3.3/10

improving · +0.2 vs previous 14 d

Stress level

Daily log

6.8/10

stable · +0.1 vs previous 14 d

Steps

Wearable

3,456

stable · +147 vs previous 14 d

Adherence

Companion

48.4 %

stable · -1.7 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 19 from the failing basin, 72 from restoration.

Would help

NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 75%
SC-12 Supportive Compound
76% improved among 51 similar · onset 6 d · confidence 75%
CR-01 Clinician Review
100% improved among 8 similar · onset 5 d · confidence 75%

Would not help

GI-04 GI Support Protocol
already tried, no meaningful change
Keep fat low
GI +4 next day on high-intake days · n 24
Keep histamine low
GI +3.8 next day on high-intake days · n 23

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+4detractor · 95%
Histamine load
+3.8detractor · 95%
Alcohol
-1.2no signal · 26%
Spicy / capsaicin
+0.7no signal · 18%
Simple carbohydrates
+0.6no signal · 15%
Insoluble fibre
0no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 62
- WearableHRV 36 ms, trending down
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 29/100
- Daily logFibre intake low in recent food logs
Mucosal barrier integrity ↓50
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 66 and rising
Drug metabolism and exposure ↑20
- BloodToxicity index 47
Autonomic recovery ↓20
- Wearable3,456 steps/day

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 3.1 · butyrate capacity 29/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 37 ms
Sleep: 6.9 h
Steps: 4,136
Resting HR: 71 bpm

Daily log: GI score 66, nutritional resilience 39, adherence 48.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01813	47%	S01	NP-02	no change	40
P-01327	39%	S01	GI-04	improved	56
P-01688	33%	S01	GI-04	improved	40
P-01310	29%	S01	—	—	57
P-01877	25%	S01	CR-01	improved	67
P-01821	20%	S01	—	—	58
P-01823	20%	S01	—	—	57
P-01695	19%	S01	—	—	30
P-01731	19%	S01	ME-01	improved	32
P-01846	19%	S01	—	—	37
P-01452	34%	S02	GI-04	improved	46
P-01635	33%	S02	GI-04	improved	49