Patient P-01689

Synthetic patientNBL-101 · Day 105 · 25–34 · F · baseline S13Steering view · 3D Open companion preview

Therapy response

Improving

Tolerance

Deteriorating

GI state

Deteriorating

Inflammatory state

Deteriorating

Nutritional resilience

Stable

Discontinuation risk

33%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S13
Day 72 BR-03 recommended — Behavioural Recommendation BR-03
Day 73 Patient accepted — Started BR-03 in the companion
Day 80 No meaningful change — Behavioural Recommendation BR-03
Day 84 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 84.

Primary contributors, last 14 days

Toxicity+11
GI instability+8
Inflammatory activity+7
Treatment adherence-3

What helped?

Behavioural Recommendation BR-03Day 72
Result: no meaningful change

LIFE OS recommendation

No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

31/100

worsening · +8.9 vs previous 14 d

Toxicity

Blood

24.6/100

worsening · +1.2 vs previous 14 d

Sleep quality

Wearable

45.3/100

worsening · -6.6 vs previous 14 d

Energy level

Daily log

4.7/10

worsening · -0.8 vs previous 14 d

Stress level

Daily log

4.2/10

worsening · +0.7 vs previous 14 d

Steps

Wearable

3,369

worsening · -604 vs previous 14 d

Adherence

Companion

88 %

worsening · -5.0 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 57 from the failing basin, 33 from restoration.

Would help

No untried action with strong evidence. Compose one from primitives.

Would not help

BR-03 Behavioural Recommendation
already tried, no meaningful change
Keep histamine low
GI +5.9 next day on high-intake days · n 22

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+5.9detractor · 95%
Insoluble fibre
-2.2no signal · 51%
Spicy / capsaicin
-2.1no signal · 42%
Simple carbohydrates
-1.6no signal · 31%
Dietary fat load
+1no signal · 22%
Alcohol
-0.6no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Autonomic recovery ↑40
- Wearable3,369 steps/day
- WearableShort sleep window
Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
Inflammatory signalling ↑25
- DNAIL6 -174 variant raises baseline inflammatory tone
Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 3.1 · butyrate capacity 61/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 67 ms
Sleep: 6.8 h
Steps: 3,940
Resting HR: 58 bpm

Daily log: GI score 31, nutritional resilience 59, adherence 88.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01377	43%	S11	AD-05	no change	42
P-01541	43%	S09	AD-05	no change	43
P-01483	41%	S14	AD-05	no change	35
P-01679	37%	S12	AD-05	no change	39
P-01804	31%	S19	AD-05	improved	61
P-01848	28%	S05	AD-05	no change	23
P-01773	26%	S05	AD-05	improved	27
P-01313	35%	S01	BR-03	improved	32
P-01350	35%	S19	BR-03	no change	34
P-01450	34%	S09	BR-03	no change	36
P-01468	31%	S06	BR-03	no change	41
P-01329	26%	S08	BR-03	improved	79