Patient P-01746

Synthetic patientNBL-101 · Day 102 · 75+ · M · baseline S14Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Improving

GI state

Improving

Inflammatory state

Improving

Nutritional resilience

Improving

Discontinuation risk

74%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 31 NP-02 recommended — Dietary Support Protocol NP-02
Day 32 Patient accepted — Started NP-02 in the companion
Day 42 GI symptom burden −25% vs expected — Dietary Support Protocol NP-02
Day 48 Tolerance state changed — Unstable → Improving
Day 55 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 68 ME-01 recommended — Monitoring Escalation ME-01
Day 69 Patient accepted — Started ME-01 in the companion
Day 72 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 55.

Primary contributors, last 14 days

GI instability-25
Inflammatory activity-22
Nutritional resilience+10
Toxicity-8

What helped?

Dietary Support Protocol NP-02Day 31
Result: symptom burden −25%
Monitoring Escalation ME-01Day 68
Result: deterioration detected before clinical escalation

LIFE OS recommendation

GI Support Protocol GI-04

80%

probability of meaningful tolerance improvement

284 similar trajectories
84% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

40.2/100

improving · -5.2 vs previous 14 d

Toxicity

Blood

31.1/100

stable · -1.2 vs previous 14 d

Sleep quality

Wearable

49.6/100

stable · +0.4 vs previous 14 d

Energy level

Daily log

4.6/10

stable · -0.1 vs previous 14 d

Stress level

Daily log

4.8/10

improving · -0.5 vs previous 14 d

Steps

Wearable

4,394

worsening · -223 vs previous 14 d

Adherence

Companion

46.9 %

stable · -1.1 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards restoration · 48 from the failing basin, 41 from restoration.

Would help

GI-04 GI Support Protocol
73% improved among 124 similar · onset 8 d · confidence 80%
CR-01 Clinician Review
100% improved among 6 similar · onset 5 d · confidence 66%

Would not help

Keep fat low
GI +7.1 next day on high-intake days · n 23
Keep histamine low
GI +6.4 next day on high-intake days · n 20

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+7.1detractor · 95%
Histamine load
+6.4detractor · 95%
Simple carbohydrates
-2.1no signal · 40%
Insoluble fibre
-1.7no signal · 30%
Spicy / capsaicin
+1.6no signal · 28%
Alcohol
-0.8no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓35
- MicrobiomeButyrate capacity 22/100
Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
DPYD *2A heterozygous
Slower drug clearance
CYP2D6 Rapid metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 3.1 · butyrate capacity 22/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 53 ms
Sleep: 6.4 h
Steps: 3,767
Resting HR: 68 bpm

Daily log: GI score 40, nutritional resilience 51, adherence 47.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01377	26%	S11	AD-05	no change	42
P-01483	25%	S14	AD-05	no change	35
P-01689	25%	S13	BR-03	no change	50
P-01708	30%	S07	CR-01	improved	59
P-01371	29%	S06	CR-01	improved	63
P-01696	26%	S20	CR-01	improved	59
P-01430	25%	S05	CR-01	improved	54
P-01442	25%	S13	CR-01	improved	61
P-01388	24%	S17	CR-01	improved	59
P-01767	25%	S14	DT-01	no change	63
P-01458	51%	S14	GI-04	improved	44
P-01559	49%	S06	GI-04	improved	42