Patient P-01884

Synthetic patientNBL-101 · Day 108 · 55–64 · M · baseline S19Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Favorable

GI state

Deteriorating

Inflammatory state

Deteriorating

Nutritional resilience

Declining

Discontinuation risk

53%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S19
Day 12 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 14 GI-04 recommended — GI Support Protocol GI-04
Day 15 Patient accepted — Started GI-04 in the companion
Day 23 No meaningful change — GI Support Protocol GI-04

What changed?

Trajectory began diverging from predicted response on Day 12.

Primary contributors, last 14 days

GI instability+29
Inflammatory activity+20
Nutritional resilience-16
Treatment adherence+4
Toxicity-2

What helped?

GI Support Protocol GI-04Day 14
Result: no meaningful change

LIFE OS recommendation

Clinician Review CR-01

72%

probability of meaningful tolerance improvement

284 similar trajectories
100% showed improvement
median effect visible after 5 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

30.3/100

worsening · +1.6 vs previous 14 d

Toxicity

Blood

19.3/100

improving · -9.9 vs previous 14 d

Sleep quality

Wearable

28.9/100

improving · +1.7 vs previous 14 d

Energy level

Daily log

4.8/10

stable · +0.1 vs previous 14 d

Stress level

Daily log

5.9/10

stable · +0.0 vs previous 14 d

Steps

Wearable

2,436

improving · +381 vs previous 14 d

Adherence

Companion

96.8 %

stable · -2.9 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 59 from the failing basin, 30 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 10 similar · onset 3 d · confidence 60%

Would not help

GI-04 GI Support Protocol
already tried, no meaningful change
Keep histamine low
GI +7.4 next day on high-intake days · n 23
Keep simple carbs low
GI +5.9 next day on high-intake days · n 19

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+7.4detractor · 95%
Simple carbohydrates
+5.9detractor · 95%
Dietary fat load
-1.6no signal · 29%
Alcohol
-1.3no signal · 17%
Insoluble fibre
-0.9no signal · 15%
Spicy / capsaicin
+0.8no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
Inflammatory signalling ↑35
- MicrobiomeBacteroides fragilis expansion
- WearableHRV 24 ms, trending down
Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
Autonomic recovery ↓20
- Wearable2,436 steps/day

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.3 · butyrate capacity 46/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 33 ms
Sleep: 6.3 h
Steps: 3,490
Resting HR: 66 bpm

Daily log: GI score 30, nutritional resilience 57, adherence 97.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
A 15-minute walk after lunch
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01804	43%	S19	AD-05	improved	61
P-01541	32%	S09	AD-05	no change	43
P-01377	31%	S11	AD-05	no change	42
P-01483	30%	S14	AD-05	no change	35
P-01679	29%	S12	AD-05	no change	39
P-01773	27%	S05	AD-05	improved	27
P-01350	31%	S19	BR-03	no change	34
P-01313	29%	S01	BR-03	improved	32
P-01689	29%	S13	BR-03	no change	50
P-01468	27%	S06	BR-03	no change	41
P-01450	26%	S09	BR-03	no change	36
P-01430	43%	S05	CR-01	improved	54