Patient P-03031
Therapy response
Declining
Tolerance
Deteriorating
GI state
Stable
Inflammatory state
Stable
Nutritional resilience
Declining
Discontinuation risk
47%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S16
- Day 102 CR-01 recommended — Clinician Review CR-01
- Day 103 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 103 Patient accepted — Started CR-01 in the companion
- Day 108 Deterioration detected before clinical escalation — Clinician Review CR-01
What changed?
Trajectory began diverging from predicted response on Day 103.
Primary contributors, last 14 days
- Toxicity+9
- Treatment adherence-8
- Nutritional resilience-4
- Inflammatory activity+3
- GI instability+2
What helped?
- Clinician Review CR-01Day 102Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
52%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log3.1/10
worsening · -0.9 vs previous 14 d
Stress level
Daily log7.1/10
worsening · +0.5 vs previous 14 d
Pessimism score
Daily log5.5/10
worsening · +0.9 vs previous 14 d
Sleep quality
Wearable21.8/100
worsening · -4.5 vs previous 14 d
Libido
Daily log2.1/10
worsening · -1.0 vs previous 14 d
HRV
Wearable22 ms
worsening · -2.3 vs previous 14 d
Toxicity
Blood43.5/100
worsening · +16.5 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 36 from the failing basin, 51 from restoration.
Would help
- GI-04 GI Support Protocol74% improved among 34 similar · onset 8 d · confidence 48%
- DT-01 Dosing / Timing Recommendation82% improved among 11 similar · onset 5 d · confidence 52%
- SC-12 Supportive Compound89% improved among 9 similar · onset 6 d · confidence 52%
- More proteinGI -3.7 next day on high-intake days · n 14
Would not help
- AD-05 Adherence Supportonly 27% improved among 11 similar
- Keep histamine lowGI +3.4 next day on high-intake days · n 26
- Keep lactose lowGI +1.9 next day on high-intake days · n 24
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-3.7supporter · 95%
- Histamine load+3.4detractor · 95%
- Lactose+1.9detractor · 72%
- Alcohol-0.6no signal · 20%
- Caffeine-0.3no signal · 15%
- Dietary fat load0no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 50
- WearableHRV 22 ms, trending down
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 48 and rising
- Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Drug metabolism and exposure ↑20
- BloodToxicity index 44
- Autonomic recovery ↓20
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.6 · butyrate capacity 46/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 21 ms
- Sleep
- 6.4 h
- Steps
- 4,955
- Resting HR
- 67 bpm
Daily log: GI score 48, nutritional resilience 45, adherence 74.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03204 | 28% | S16 | AD-05 | improved | 48 |
| P-03105 | 26% | S12 | AD-05 | no change | 60 |
| P-03111 | 26% | S07 | AD-05 | no change | 48 |
| P-03482 | 26% | S05 | AD-05 | no change | 67 |
| P-03351 | 25% | S07 | AD-05 | no change | 51 |
| P-03369 | 24% | S18 | AD-05 | no change | 37 |
| P-03424 | 24% | S12 | AD-05 | improved | 41 |
| P-03034 | 23% | S14 | AD-05 | no change | 30 |
| P-03187 | 23% | S12 | AD-05 | no change | 80 |
| P-03380 | 23% | S16 | AD-05 | improved | 34 |
| P-03129 | 22% | S18 | AD-05 | no change | 32 |
| P-03277 | 25% | S14 | BR-03 | improved | 41 |