Patient P-03110

Synthetic patientONX-7 · Day 142 · 35–44 · M · baseline S15Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Deteriorating

GI state

Deteriorating

Inflammatory state

Deteriorating

Nutritional resilience

Declining

Discontinuation risk

67%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 ONX-7 started — Baseline state S15
Day 58 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 63 GI-04 recommended — GI Support Protocol GI-04
Day 64 Patient accepted — Started GI-04 in the companion
Day 65 SC-12 recommended — Supportive Compound SC-12
Day 66 Patient accepted — Started SC-12 in the companion
Day 72 GI symptom burden −37% vs expected — GI Support Protocol GI-04
Day 72 GI symptom burden −22% vs expected — Supportive Compound SC-12
Day 78 Tolerance state changed — Unstable → Improving
Day 78 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 58.

Primary contributors, last 14 days

GI instability+14
Nutritional resilience-7
Inflammatory activity+5
Toxicity+4
Treatment adherence-3

What helped?

GI Support Protocol GI-04Day 63
Result: symptom burden −37%
Supportive Compound SC-12Day 65
Result: symptom burden −22%

LIFE OS recommendation

Dosing / Timing Recommendation DT-01

64%

probability of meaningful tolerance improvement

284 similar trajectories
82% showed improvement
median effect visible after 5 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Energy level

Daily log

2.9/10

worsening · -0.8 vs previous 14 d

Stress level

Daily log

6/10

worsening · +0.3 vs previous 14 d

Pessimism score

Daily log

6/10

worsening · +0.3 vs previous 14 d

Sleep quality

Wearable

27.6/100

worsening · -4.8 vs previous 14 d

Libido

Daily log

3/10

worsening · -0.3 vs previous 14 d

HRV

Wearable

49.4 ms

stable · -1.4 vs previous 14 d

Toxicity

Blood

37.2/100

worsening · +8.9 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 42 from the failing basin, 46 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 11 similar · onset 3 d · confidence 64%
DT-01 Dosing / Timing Recommendation
82% improved among 11 similar · onset 5 d · confidence 64%
NP-02 Dietary Support Protocol
57% improved among 14 similar · onset 10 d · confidence 64%
More protein
GI -4 next day on high-intake days · n 21

Would not help

AD-05 Adherence Support
only 27% improved among 11 similar
Keep fat low
GI +3.6 next day on high-intake days · n 28
Keep histamine low
GI +3.6 next day on high-intake days · n 26
Keep alcohol low
GI +2.2 next day on high-intake days · n 18

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Protein
-4supporter · 95%
Dietary fat load
+3.6detractor · 95%
Histamine load
+3.6detractor · 95%
Alcohol
+2.2detractor · 60%
Lactose
+0.9no signal · 24%
Caffeine
+0.1no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 50 and rising
- WearableSleep 5.8 h, below personal baseline
Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 36/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Autonomic recovery ↓65
- WearableResting HR 77 bpm
- Wearable1,131 steps/day
- WearableShort sleep window
Inflammatory signalling ↑50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 43

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Intermediate metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 3 · butyrate capacity 36/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 52 ms
Sleep: 6.2 h
Steps: 2,166
Resting HR: 75 bpm

Daily log: GI score 50, nutritional resilience 47, adherence 56.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-03105	29%	S12	AD-05	no change	60
P-03204	28%	S16	AD-05	improved	48
P-03111	27%	S07	AD-05	no change	48
P-03351	27%	S07	AD-05	no change	51
P-03424	27%	S12	AD-05	improved	41
P-03482	26%	S05	AD-05	no change	67
P-03034	25%	S14	AD-05	no change	30
P-03158	25%	S17	AD-05	no change	37
P-03369	25%	S18	AD-05	no change	37
P-03122	24%	S13	AD-05	no change	40
P-03380	24%	S16	AD-05	improved	34
P-03277	27%	S14	BR-03	improved	41