Patient P-03159
Therapy response
Unstable
Tolerance
Favorable
GI state
Stable
Inflammatory state
Stable
Nutritional resilience
Stable
Discontinuation risk
58%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 39 NP-02 recommended — Dietary Support Protocol NP-02
- Day 40 Patient accepted — Started NP-02 in the companion
- Day 50 GI symptom burden −19% vs expected — Dietary Support Protocol NP-02
- Day 56 Tolerance state changed — Unstable → Improving
- Day 67 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 67 GI-04 recommended — GI Support Protocol GI-04
- Day 68 Patient accepted — Started GI-04 in the companion
- Day 76 GI symptom burden −31% vs expected — GI Support Protocol GI-04
- Day 82 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 67.
Primary contributors, last 14 days
- Toxicity-3
- GI instability-2
What helped?
- Dietary Support Protocol NP-02Day 39Result: symptom burden −19%
- GI Support Protocol GI-04Day 67Result: symptom burden −31%
LIFE OS recommendation
Clinician Review CR-01
74%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 100% showed improvement
- median effect visible after 5 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log2.7/10
stable · +0.1 vs previous 14 d
Stress level
Daily log6.2/10
stable · -0.2 vs previous 14 d
Pessimism score
Daily log5.6/10
stable · -0.0 vs previous 14 d
Sleep quality
Wearable14/100
worsening · -1.8 vs previous 14 d
Libido
Daily log3.5/10
improving · +0.4 vs previous 14 d
HRV
Wearable25 ms
worsening · -2.1 vs previous 14 d
Toxicity
Blood33.7/100
improving · -2.7 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 33 from the failing basin, 56 from restoration.
Would help
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 62%
- DT-01 Dosing / Timing Recommendation63% improved among 8 similar · onset 5 d · confidence 62%
- CR-01 Clinician Review100% improved among 5 similar · onset 5 d · confidence 62%
- More proteinGI -7.3 next day on high-intake days · n 17
Would not help
- AD-05 Adherence Supportonly 25% improved among 12 similar
- Keep fat lowGI +5.9 next day on high-intake days · n 23
- Keep lactose lowGI +5.3 next day on high-intake days · n 23
- Keep histamine lowGI +5.2 next day on high-intake days · n 23
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-7.3supporter · 95%
- Dietary fat load+5.9detractor · 95%
- Lactose+5.3detractor · 95%
- Histamine load+5.2detractor · 95%
- Alcohol+0.4no signal · 15%
- Caffeine0no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓70
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- WearableSleep 5.2 h, below personal baseline
- Inflammatory signalling ↓60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 48
- WearableHRV 25 ms, trending down
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 42/100
- MicrobiomeF. prausnitzii depleted
- Autonomic recovery ↑45
- WearableResting HR 80 bpm
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Intermediate metabolizerExpected exposure
Microbiome
Shannon diversity 2.5 · butyrate capacity 42/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 24 ms
- Sleep
- 5.7 h
- Steps
- 4,870
- Resting HR
- 78 bpm
Daily log: GI score 45, nutritional resilience 51, adherence 51.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03226 | 50% | S05 | GI-04 | improved | 43 |
| P-03300 | 46% | S14 | GI-04 | improved | 46 |
| P-03090 | 44% | S02 | GI-04 | improved | 48 |
| P-03145 | 40% | S14 | GI-04 | improved | 51 |
| P-03123 | 38% | S14 | GI-04 | improved | 50 |
| P-03070 | 37% | S14 | GI-04 | improved | 51 |
| P-03430 | 37% | S14 | SC-12 | improved | 45 |
| P-03037 | 36% | S14 | NP-02 | improved | 43 |
| P-03049 | 36% | S14 | GI-04 | improved | 49 |
| P-03146 | 36% | S14 | GI-04 | improved | 53 |
| P-03225 | 36% | S19 | GI-04 | improved | 50 |
| P-03003 | 35% | S08 | SC-12 | improved | 53 |