Patient P-03160
Therapy response
Improving
Tolerance
Improving
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
52%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S18
- Day 61 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 102 GI-04 recommended — GI Support Protocol GI-04
- Day 103 Patient declined — Not now
What changed?
Trajectory began diverging from predicted response on Day 61.
Primary contributors, last 14 days
- GI instability+14
- Nutritional resilience-10
- Treatment adherence-9
- Inflammatory activity+6
- Toxicity-4
What helped?
- GI Support Protocol GI-04Day 102Declined by patient
LIFE OS recommendation
GI Support Protocol GI-04
51%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 84% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log4.8/10
worsening · -1.3 vs previous 14 d
Stress level
Daily log4.7/10
worsening · +0.7 vs previous 14 d
Pessimism score
Daily log3.8/10
worsening · +0.5 vs previous 14 d
Sleep quality
Wearable52.2/100
worsening · -10.1 vs previous 14 d
Libido
Daily log3.7/10
worsening · -0.3 vs previous 14 d
HRV
Wearable45.3 ms
worsening · -4.3 vs previous 14 d
Toxicity
Blood31.4/100
stable · +0.4 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 52 from the failing basin, 37 from restoration.
Would help
- GI-04 GI Support Protocol85% improved among 26 similar · onset 8 d · confidence 46%
- DT-01 Dosing / Timing Recommendation86% improved among 14 similar · onset 5 d · confidence 55%
- HY-01 Hydration Protocol67% improved among 9 similar · onset 4 d · confidence 55%
- More proteinGI -2.3 next day on high-intake days · n 14
Would not help
- AD-05 Adherence Supportonly 20% improved among 10 similar
- Keep fat lowGI +3 next day on high-intake days · n 22
- Keep caffeine lowGI +2.3 next day on high-intake days · n 18
- Keep lactose lowGI +2.2 next day on high-intake days · n 18
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+3detractor · 95%
- Caffeine+2.3detractor · 85%
- Protein-2.3supporter · 63%
- Lactose+2.2detractor · 76%
- Histamine load+0.5no signal · 18%
- Alcohol+0.3no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 32/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 44
- Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
DNA
Fictional pharmacogenomic panel
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 3.1 · butyrate capacity 32/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 48 ms
- Sleep
- 7.3 h
- Steps
- 8,575
- Resting HR
- 70 bpm
Daily log: GI score 44, nutritional resilience 46, adherence 84.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03346 | 40% | S17 | GI-04 | improved | 71 |
| P-03382 | 38% | S01 | GI-04 | improved | 56 |
| P-03379 | 37% | S12 | GI-04 | improved | 51 |
| P-03225 | 35% | S19 | GI-04 | improved | 50 |
| P-03484 | 35% | S07 | DT-01 | improved | 49 |
| P-03110 | 34% | S15 | GI-04 | improved | 52 |
| P-03166 | 34% | S20 | CR-01 | improved | 62 |
| P-03179 | 34% | S05 | GI-04 | improved | 52 |
| P-03201 | 34% | S15 | GI-04 | improved | 68 |
| P-03252 | 34% | S13 | SC-12 | improved | 68 |
| P-03255 | 34% | S01 | HY-01 | improved | 53 |
| P-03031 | 33% | S16 | CR-01 | improved | 49 |