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Patient P-03160

Synthetic patientONX-7 · Day 106 · 65–74 · M · baseline S18Steering view · 3DOpen companion preview
Therapy response
Improving
Tolerance
Improving
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
52%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 ONX-7 started — Baseline state S18
  2. Day 61 Trajectory diverged from prediction — Observed response fell below the model's expected path.
  3. Day 102 GI-04 recommended — GI Support Protocol GI-04
  4. Day 103 Patient declined — Not now

What changed?

Trajectory began diverging from predicted response on Day 61.

Primary contributors, last 14 days
  • GI instability+14
  • Nutritional resilience-10
  • Treatment adherence-9
  • Inflammatory activity+6
  • Toxicity-4

What helped?

  • GI Support Protocol GI-04Day 102
    Declined by patient
LIFE OS recommendation
GI Support Protocol GI-04
51%
probability of meaningful tolerance improvement
  • 284 similar trajectories
  • 84% showed improvement
  • median effect visible after 8 days
View similar patientsSimulateAdd to intervention cohortAll evidence

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Energy level
Daily log
4.8/10
worsening · -1.3 vs previous 14 d
Stress level
Daily log
4.7/10
worsening · +0.7 vs previous 14 d
Pessimism score
Daily log
3.8/10
worsening · +0.5 vs previous 14 d
Sleep quality
Wearable
52.2/100
worsening · -10.1 vs previous 14 d
Libido
Daily log
3.7/10
worsening · -0.3 vs previous 14 d
HRV
Wearable
45.3 ms
worsening · -4.3 vs previous 14 d
Toxicity
Blood
31.4/100
stable · +0.4 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →

Heading towards failing · 52 from the failing basin, 37 from restoration.

Would help
  • GI-04 GI Support Protocol
    85% improved among 26 similar · onset 8 d · confidence 46%
  • DT-01 Dosing / Timing Recommendation
    86% improved among 14 similar · onset 5 d · confidence 55%
  • HY-01 Hydration Protocol
    67% improved among 9 similar · onset 4 d · confidence 55%
  • More protein
    GI -2.3 next day on high-intake days · n 14
Would not help
  • AD-05 Adherence Support
    only 20% improved among 10 similar
  • Keep fat low
    GI +3 next day on high-intake days · n 22
  • Keep caffeine low
    GI +2.3 next day on high-intake days · n 18
  • Keep lactose low
    GI +2.2 next day on high-intake days · n 18
State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

  • Dietary fat load
    +3detractor · 95%
  • Caffeine
    +2.3detractor · 85%
  • Protein
    -2.3supporter · 63%
  • Lactose
    +2.2detractor · 76%
  • Histamine load
    +0.5no signal · 18%
  • Alcohol
    +0.3no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure
  • Butyrate / short-chain fatty acid production ↓80
    • MicrobiomeButyrate capacity 32/100
    • MicrobiomeF. prausnitzii depleted
    • Daily logFibre intake low in recent food logs
  • Inflammatory signalling ↑70
    • DNAIL6 -174 variant raises baseline inflammatory tone
    • MicrobiomeBacteroides fragilis expansion
    • BloodInflammatory load index 44
  • Drug metabolism and exposure ↑40
    • DNACYP2D6 poor metabolizer → higher exposure
  • Mucosal barrier integrity ↓30
    • MicrobiomeAkkermansia low → thinner mucus layer
DNA
Fictional pharmacogenomic panel
  • IL6 -174 G/C
    Higher inflammatory tone
  • CYP2D6 Poor metabolizer
    Higher exposure at standard dose
Microbiome
Shannon diversity 3.1 · butyrate capacity 32/100
  • Akkermansia muciniphilaLow
  • Faecalibacterium prausnitziiLow
  • Bacteroides fragilisHigh
  • Bifidobacterium longumLow
  • EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
HRV
48 ms
Sleep
7.3 h
Steps
8,575
Resting HR
70 bpm
Daily log: GI score 44, nutritional resilience 46, adherence 84.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview
What to eat
  • Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
  • Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
  • Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
  • Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
  • Track each bowel movement today: time, stool form, urgency, overnight waking
  • Keep the current walking rhythm
  • Keep the sleep window steady
  • Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
  • Take the scheduled dose as agreed with your care team
  • Electrolyte solution, one sachet after any loose stool
  • Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Sort by similaritySort by interventionSort by outcomeSort by stateSort by response
PatientSimilarityBaselineInterventionOutcomeResponse today
P-0310533%S12AD-05no change60
P-0320432%S16AD-05improved48
P-0348230%S05AD-05no change67
P-0311129%S07AD-05no change48
P-0335129%S07AD-05no change51
P-0342429%S12AD-05improved41
P-0318728%S12AD-05no change80
P-0336927%S18AD-05no change37
P-0303426%S14AD-05no change30
P-0315825%S17AD-05no change37
P-0327729%S14BR-03improved41
P-0320827%S02BR-03improved57