Patient P-03172
Therapy response
Declining
Tolerance
Favorable
GI state
Favorable
Inflammatory state
Favorable
Nutritional resilience
Favorable
Discontinuation risk
13%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S17
- Day 15 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 18 DT-01 recommended — Dosing / Timing Recommendation DT-01
- Day 19 Patient accepted — Started DT-01 in the companion
- Day 24 No meaningful change — Dosing / Timing Recommendation DT-01
What changed?
Trajectory began diverging from predicted response on Day 15.
Primary contributors, last 14 days
- GI instability-4
- Toxicity+3
- Treatment adherence-2
What helped?
- Dosing / Timing Recommendation DT-01Day 18Result: no meaningful change
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log5.6/10
stable · -0.1 vs previous 14 d
Stress level
Daily log4.1/10
stable · -0.1 vs previous 14 d
Pessimism score
Daily log4.4/10
stable · +0.1 vs previous 14 d
Sleep quality
Wearable44.8/100
improving · +2.3 vs previous 14 d
Libido
Daily log5.2/10
stable · -0.0 vs previous 14 d
HRV
Wearable34.5 ms
stable · +0.9 vs previous 14 d
Toxicity
Blood16.7/100
worsening · +8.3 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 72 from the failing basin, 30 from restoration.
Would help
- No untried action with strong evidence. Compose one from primitives.
- More proteinGI -5.2 next day on high-intake days · n 19
Would not help
- DT-01 Dosing / Timing Recommendationalready tried, no meaningful change
- AD-05 Adherence Supportonly 27% improved among 15 similar
- Keep fat lowGI +4.4 next day on high-intake days · n 18
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-5.2supporter · 95%
- Dietary fat load+4.4detractor · 95%
- Lactose+1.8no signal · 47%
- Histamine load-1no signal · 26%
- Alcohol+0.8no signal · 15%
- Caffeine-0.4no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 41/100
- MicrobiomeF. prausnitzii depleted
- Inflammatory signalling ↓35
- MicrobiomeBacteroides fragilis expansion
- WearableHRV 35 ms, trending down
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
DNA
Fictional pharmacogenomic panel
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 3 · butyrate capacity 41/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 36 ms
- Sleep
- 7.0 h
- Steps
- 9,734
- Resting HR
- 59 bpm
Daily log: GI score 17, nutritional resilience 66, adherence 90.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03144 | 51% | S16 | HY-01 | improved | 52 |
| P-03179 | 47% | S05 | GI-04 | improved | 52 |
| P-03233 | 46% | S19 | DT-01 | improved | 47 |
| P-03328 | 46% | S15 | GI-04 | improved | 59 |
| P-03484 | 44% | S07 | DT-01 | improved | 49 |
| P-03143 | 43% | S11 | DT-01 | improved | 49 |
| P-03255 | 43% | S01 | HY-01 | improved | 53 |
| P-03215 | 42% | S16 | HY-01 | improved | 44 |
| P-03317 | 42% | S08 | HY-01 | improved | 45 |
| P-03204 | 40% | S16 | AD-05 | improved | 48 |
| P-03244 | 39% | S08 | DT-01 | improved | 53 |
| P-03375 | 39% | S09 | DT-01 | improved | 52 |