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Patient P-03177

Synthetic patientONX-7 · Day 123 · 35–44 · M · baseline S01Steering view · 3DOpen companion preview
Therapy response
Unstable
Tolerance
Deteriorating
GI state
Stable
Inflammatory state
Deteriorating
Nutritional resilience
Stable
Discontinuation risk
31%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 ONX-7 started — Baseline state S01
  2. Day 21 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 21.

Primary contributors, last 14 days
  • Toxicity+10
  • Inflammatory activity+4
  • Treatment adherence-4
  • GI instability+3
  • Nutritional resilience+3

What helped?

No interventions yet.

    LIFE OS recommendation
    Dosing / Timing Recommendation DT-01
    55%
    probability of meaningful tolerance improvement
    • 284 similar trajectories
    • 77% showed improvement
    • median effect visible after 5 days
    View similar patientsSimulateAdd to intervention cohortAll evidence

    Daily trackers

    Molecule settings

    The trackers this program marks as important, last 14 days vs the 14 before.

    Energy level
    Daily log
    4.5/10
    worsening · -0.4 vs previous 14 d
    Stress level
    Daily log
    3.7/10
    worsening · +0.5 vs previous 14 d
    Pessimism score
    Daily log
    4.7/10
    worsening · +0.4 vs previous 14 d
    Sleep quality
    Wearable
    45/100
    worsening · -3.1 vs previous 14 d
    Libido
    Daily log
    4.9/10
    worsening · -0.2 vs previous 14 d
    HRV
    Wearable
    60.9 ms
    stable · -2.6 vs previous 14 d
    Toxicity
    Blood
    17.6/100
    worsening · +1.3 vs previous 14 d
    This trajectory is decaying — what would help, what would not
    Steering view →

    Heading towards failing · 43 from the failing basin, 56 from restoration.

    Would help
    • DT-01 Dosing / Timing Recommendation
      77% improved among 13 similar · onset 5 d · confidence 56%
    • HY-01 Hydration Protocol
      60% improved among 10 similar · onset 4 d · confidence 56%
    • More protein
      GI -4.7 next day on high-intake days · n 19
    Would not help
    • AD-05 Adherence Support
      only 31% improved among 13 similar
    • Keep histamine low
      GI +5 next day on high-intake days · n 20
    • Keep lactose low
      GI +2.9 next day on high-intake days · n 29
    State influencers · digestive

    Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

    • Histamine load
      +5detractor · 95%
    • Protein
      -4.7supporter · 95%
    • Lactose
      +2.9detractor · 76%
    • Alcohol
      +1.3no signal · 23%
    • Caffeine
      -1.1no signal · 27%
    • Dietary fat load
      +0.1no signal · 15%

    Biological layers

    Which pathways look influenced, and by which layer of this person's biology.

    Pathways under pressure
    • Mucosal barrier integrity ↓60
      • DNAFUT2 non-secretor lowers mucosal fucosylation
      • MicrobiomeAkkermansia low → thinner mucus layer
    • Autonomic recovery ↑25
      • WearableResting HR 81 bpm
    • Inflammatory signalling ↑20
      • MicrobiomeBacteroides fragilis expansion
    DNA
    Fictional pharmacogenomic panel
    • FUT2 rs601338 AA (non-secretor)
      Reduced mucosal fucosylation
    • CYP2D6 Normal metabolizer
      Expected exposure
    Microbiome
    Shannon diversity 3 · butyrate capacity 52/100
    • Akkermansia muciniphilaLow
    • Faecalibacterium prausnitziiNormal
    • Bacteroides fragilisHigh
    • Bifidobacterium longumLow
    • EnterobacteriaceaeNormal
    Wearable, last 14 days
    daily evolution fed into the runtime
    HRV
    64 ms
    Sleep
    7.1 h
    Steps
    4,540
    Resting HR
    77 bpm
    Daily log: GI score 40, nutritional resilience 55, adherence 85.

    What this patient sees in NostraAI

    The content that steers the trajectory: what to eat, what to do, what to take.

    Open companion preview
    What to eat
    • Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
    • Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
    • Keep fibre steady; no new sources this week
    • Avoid known triggers for now: fried or oily food, dairy, alcohol
    What to do
    • Track each bowel movement today: time, stool form, urgency, overnight waking
    • A 15-minute walk after lunch
    • Keep the sleep window steady
    • Keep hydration steady: small amounts through the day rather than large volumes at once
    What to take
    • Take the scheduled dose as agreed with your care team
    • Electrolyte solution, one sachet after any loose stool
    • Fictional demo item: continue vitamin D as before

    284 biologically similar trajectories

    Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

    Sort by similaritySort by interventionSort by outcomeSort by stateSort by response
    PatientSimilarityBaselineInterventionOutcomeResponse today
    P-0323542%S13GI-04improved29
    P-0330736%S03ME-01improved17
    P-0327734%S14BR-03improved41
    P-0320432%S16AD-05improved48
    P-0337332%S17BR-03improved34
    P-0301331%S07GI-04improved30
    P-0342431%S12AD-05improved41
    P-0342631%S18BR-03improved27
    P-0337530%S09DT-01improved52
    P-0338030%S16AD-05improved34
    P-0344230%S11DT-01improved51
    P-0348430%S07DT-01improved49