Patient P-03218
Therapy response
Improving
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Unstable
Discontinuation risk
61%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S20
- Day 102 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 102.
Primary contributors, last 14 days
- GI instability+16
- Inflammatory activity+16
- Treatment adherence-14
- Nutritional resilience-13
- Toxicity+8
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
61%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 86% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 46
- WearableHRV 21 ms, trending down
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 29/100
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↓45
- WearableResting HR 73 bpm
- WearableShort sleep window
- Mucosal barrier integrity ↓30
- Daily logGI symptom score 50 and rising
- WearableSleep 4.8 h, below personal baseline
DNA
Fictional pharmacogenomic panel
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.4 · butyrate capacity 29/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 30 ms
- Sleep
- 5.5 h
- Steps
- 7,098
- Resting HR
- 70 bpm
Daily log: GI score 50, nutritional resilience 41, adherence 76.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03292 | 52% | S14 | — | — | 62 |
| P-03378 | 42% | S10 | — | — | 59 |
| P-03031 | 41% | S16 | CR-01 | improved | 49 |
| P-03120 | 41% | S14 | — | — | 61 |
| P-03200 | 40% | S16 | — | — | 59 |
| P-03221 | 39% | S06 | GI-04 | no change | 64 |
| P-03379 | 39% | S12 | GI-04 | improved | 51 |
| P-03160 | 38% | S18 | — | — | 63 |
| P-03346 | 38% | S17 | GI-04 | improved | 71 |
| P-03052 | 37% | S03 | — | — | 44 |
| P-03471 | 37% | S08 | — | — | 54 |
| P-03363 | 36% | S20 | — | — | 62 |