Patient P-03120
Therapy response
Favorable
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
81%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 95 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 95.
Primary contributors, last 14 days
- Inflammatory activity+21
- GI instability+20
- Nutritional resilience-16
- Toxicity+15
- Treatment adherence-5
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
67%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 61 and rising
- WearableSleep 5.8 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 27/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 61
- Autonomic recovery ↓65
- WearableResting HR 86 bpm
- Wearable612 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 41
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 1.8 · butyrate capacity 27/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 46 ms
- Sleep
- 6.8 h
- Steps
- 1,848
- Resting HR
- 83 bpm
Daily log: GI score 61, nutritional resilience 40, adherence 85.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03292 | 51% | S14 | — | — | 62 |
| P-03221 | 46% | S06 | GI-04 | no change | 64 |
| P-03285 | 46% | S04 | — | — | 54 |
| P-03379 | 46% | S12 | GI-04 | improved | 51 |
| P-03378 | 45% | S10 | — | — | 59 |
| P-03346 | 43% | S17 | GI-04 | improved | 71 |
| P-03405 | 43% | S16 | — | — | 62 |
| P-03451 | 42% | S08 | — | — | 62 |
| P-03218 | 41% | S20 | — | — | 56 |
| P-03160 | 40% | S18 | — | — | 63 |
| P-03225 | 38% | S19 | GI-04 | improved | 50 |
| P-03382 | 38% | S01 | GI-04 | improved | 56 |