Patient P-03160
Therapy response
Improving
Tolerance
Improving
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
52%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S18
- Day 61 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 102 GI-04 recommended — GI Support Protocol GI-04
- Day 103 Patient declined — Not now
What changed?
Trajectory began diverging from predicted response on Day 61.
Primary contributors, last 14 days
- GI instability+14
- Nutritional resilience-10
- Treatment adherence-9
- Inflammatory activity+6
- Toxicity-4
What helped?
- GI Support Protocol GI-04Day 102Declined by patient
LIFE OS recommendation
GI Support Protocol GI-04
51%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 84% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 32/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 44
- Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
DNA
Fictional pharmacogenomic panel
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 3.1 · butyrate capacity 32/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 48 ms
- Sleep
- 7.3 h
- Steps
- 8,575
- Resting HR
- 70 bpm
Daily log: GI score 44, nutritional resilience 46, adherence 84.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.