Patient P-03258
Therapy response
Stable
Tolerance
Deteriorating
GI state
Favorable
Inflammatory state
Favorable
Nutritional resilience
Declining
Discontinuation risk
22%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 38 NP-02 recommended — Dietary Support Protocol NP-02
- Day 39 Patient accepted — Started NP-02 in the companion
- Day 49 No meaningful change — Dietary Support Protocol NP-02
What changed?
Trajectory is tracking the baseline prediction.
Primary contributors, last 14 days
- Nutritional resilience-8
- Toxicity+4
- Inflammatory activity+3
- GI instability-2
What helped?
- Dietary Support Protocol NP-02Day 38Result: no meaningful change
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log5.1/10
stable · +0.1 vs previous 14 d
Stress level
Daily log4.6/10
improving · -0.3 vs previous 14 d
Pessimism score
Daily log4/10
stable · -0.1 vs previous 14 d
Sleep quality
Wearable29.2/100
improving · +3.6 vs previous 14 d
Libido
Daily log4.4/10
stable · +0.1 vs previous 14 d
HRV
Wearable36 ms
improving · +2.0 vs previous 14 d
Toxicity
Blood20.3/100
stable · -0.2 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 73 from the failing basin, 20 from restoration.
Would help
- No untried action with strong evidence. Compose one from primitives.
- More proteinGI -3.9 next day on high-intake days · n 26
Would not help
- AD-05 Adherence Supportonly 27% improved among 11 similar
- NP-02 Dietary Support Protocolalready tried, no meaningful change
- Keep histamine lowGI +3.9 next day on high-intake days · n 19
- Keep lactose lowGI +3.4 next day on high-intake days · n 19
- Keep caffeine lowGI +3.3 next day on high-intake days · n 18
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+3.9detractor · 95%
- Protein-3.9supporter · 95%
- Lactose+3.4detractor · 95%
- Caffeine+3.3detractor · 95%
- Alcohol-0.8no signal · 25%
- Dietary fat load+0.2no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓70
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- WearableSleep 5.9 h, below personal baseline
- Inflammatory signalling ↑60
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- WearableHRV 36 ms, trending down
- Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
- Autonomic recovery ↓20
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 3.6 · butyrate capacity 45/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 40 ms
- Sleep
- 6.0 h
- Steps
- 6,318
- Resting HR
- 71 bpm
Daily log: GI score 18, nutritional resilience 61, adherence 96.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03057 | 52% | S14 | NP-02 | improved | 64 |
| P-03178 | 50% | S11 | GI-04 | improved | 54 |
| P-03252 | 46% | S13 | SC-12 | improved | 68 |
| P-03374 | 45% | S19 | ME-01 | improved | 55 |
| P-03144 | 44% | S16 | HY-01 | improved | 52 |
| P-03208 | 44% | S02 | BR-03 | improved | 57 |
| P-03179 | 43% | S05 | GI-04 | improved | 52 |
| P-03328 | 40% | S15 | GI-04 | improved | 59 |
| P-03473 | 40% | S07 | DT-01 | improved | 70 |
| P-03213 | 39% | S02 | DT-01 | improved | 59 |
| P-03255 | 38% | S01 | HY-01 | improved | 53 |
| P-03484 | 38% | S07 | DT-01 | improved | 49 |