Patient P-03260
Therapy response
Declining
Tolerance
Stable
GI state
Unstable
Inflammatory state
Improving
Nutritional resilience
Unstable
Discontinuation risk
56%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S19
- Day 99 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 99.
Primary contributors, last 14 days
- Inflammatory activity-9
- Nutritional resilience+7
- GI instability-3
- Treatment adherence+2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
67%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log3.2/10
improving · +0.2 vs previous 14 d
Stress level
Daily log6.9/10
improving · -0.4 vs previous 14 d
Pessimism score
Daily log6.3/10
improving · -0.3 vs previous 14 d
Sleep quality
Wearable31.2/100
stable · -0.9 vs previous 14 d
Libido
Daily log2.5/10
improving · +0.2 vs previous 14 d
HRV
Wearable52.9 ms
stable · -0.9 vs previous 14 d
Toxicity
Blood49.6/100
improving · -2.2 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 35 from the failing basin, 57 from restoration.
Would help
- GI-04 GI Support Protocol74% improved among 34 similar · onset 8 d · confidence 66%
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 69%
- DT-01 Dosing / Timing Recommendation82% improved among 11 similar · onset 5 d · confidence 69%
- More proteinGI -3.7 next day on high-intake days · n 20
Would not help
- AD-05 Adherence Supportonly 18% improved among 11 similar
- Keep histamine lowGI +3.6 next day on high-intake days · n 26
- Keep alcohol lowGI +3.3 next day on high-intake days · n 23
- Keep fat lowGI +2.8 next day on high-intake days · n 24
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-3.7supporter · 95%
- Histamine load+3.6detractor · 95%
- Alcohol+3.3detractor · 95%
- Dietary fat load+2.8detractor · 95%
- Lactose+2.5detractor · 79%
- Caffeine+1no signal · 27%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 60 and rising
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 40/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↓70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 53
- Autonomic recovery ↑65
- WearableResting HR 77 bpm
- Wearable1,876 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑55
- DNADPYD *2A → slower clearance
- BloodToxicity index 50
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Intermediate metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.6 · butyrate capacity 40/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 53 ms
- Sleep
- 6.4 h
- Steps
- 2,743
- Resting HR
- 77 bpm
Daily log: GI score 60, nutritional resilience 40, adherence 67.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03105 | 22% | S12 | AD-05 | no change | 60 |
| P-03204 | 22% | S16 | AD-05 | improved | 48 |
| P-03351 | 22% | S07 | AD-05 | no change | 51 |
| P-03111 | 21% | S07 | AD-05 | no change | 48 |
| P-03482 | 21% | S05 | AD-05 | no change | 67 |
| P-03034 | 20% | S14 | AD-05 | no change | 30 |
| P-03369 | 20% | S18 | AD-05 | no change | 37 |
| P-03424 | 20% | S12 | AD-05 | improved | 41 |
| P-03122 | 19% | S13 | AD-05 | no change | 40 |
| P-03158 | 19% | S17 | AD-05 | no change | 37 |
| P-03187 | 19% | S12 | AD-05 | no change | 80 |
| P-03277 | 20% | S14 | BR-03 | improved | 41 |