Patient P-03267
Therapy response
Declining
Tolerance
Improving
GI state
Improving
Inflammatory state
Stable
Nutritional resilience
Unstable
Discontinuation risk
49%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S05
- Day 99 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 99.
Primary contributors, last 14 days
- GI instability-10
- Toxicity-6
- Treatment adherence-3
- Inflammatory activity-2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
57%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log3.6/10
improving · +0.3 vs previous 14 d
Stress level
Daily log6.7/10
improving · -0.4 vs previous 14 d
Pessimism score
Daily log5.8/10
stable · -0.2 vs previous 14 d
Sleep quality
Wearable15/100
improving · +3.2 vs previous 14 d
Libido
Daily log2.7/10
improving · +0.2 vs previous 14 d
HRV
Wearable43.2 ms
stable · +0.7 vs previous 14 d
Toxicity
Blood46.9/100
stable · -1.0 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 45 from the failing basin, 47 from restoration.
Would help
- GI-04 GI Support Protocol74% improved among 34 similar · onset 8 d · confidence 54%
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 60%
- DT-01 Dosing / Timing Recommendation89% improved among 9 similar · onset 5 d · confidence 60%
- More proteinGI -3.3 next day on high-intake days · n 17
Would not help
- AD-05 Adherence Supportonly 20% improved among 10 similar
- Keep histamine lowGI +5.7 next day on high-intake days · n 22
- Keep lactose lowGI +5 next day on high-intake days · n 19
- Keep fat lowGI +2.4 next day on high-intake days · n 20
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+5.7detractor · 95%
- Lactose+5detractor · 95%
- Protein-3.3supporter · 90%
- Dietary fat load+2.4detractor · 71%
- Alcohol+0.2no signal · 15%
- Caffeine+0.1no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 48 and rising
- WearableSleep 5.3 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 28/100
- Daily logFibre intake low in recent food logs
- Drug metabolism and exposure ↑55
- DNADPYD *2A → slower clearance
- BloodToxicity index 47
- Inflammatory signalling ↓45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 54
- Autonomic recovery ↑45
- WearableResting HR 84 bpm
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.2 · butyrate capacity 28/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 39 ms
- Sleep
- 5.2 h
- Steps
- 4,045
- Resting HR
- 85 bpm
Daily log: GI score 48, nutritional resilience 42, adherence 65.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03166 | 46% | S20 | CR-01 | improved | 62 |
| P-03465 | 44% | S17 | CR-01 | improved | 65 |
| P-03357 | 41% | S02 | CR-01 | improved | 50 |
| P-03123 | 40% | S14 | GI-04 | improved | 50 |
| P-03191 | 39% | S19 | GI-04 | improved | 51 |
| P-03201 | 39% | S15 | GI-04 | improved | 68 |
| P-03382 | 38% | S01 | GI-04 | improved | 56 |
| P-03146 | 37% | S14 | GI-04 | improved | 53 |
| P-03099 | 36% | S17 | CR-01 | improved | 55 |
| P-03225 | 36% | S19 | GI-04 | improved | 50 |
| P-03049 | 35% | S14 | GI-04 | improved | 49 |
| P-03323 | 35% | S14 | GI-04 | improved | 48 |