Patient P-03451
Therapy response
Favorable
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Stable
Nutritional resilience
Stable
Discontinuation risk
54%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S08
- Day 100 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 100.
Primary contributors, last 14 days
- Treatment adherence-15
- Toxicity+8
- Nutritional resilience+4
- GI instability+2
- Inflammatory activity+2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
62%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 27/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 59 and rising
- WearableSleep 6.1 h, below personal baseline
- Inflammatory signalling ↑50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 57
- Autonomic recovery ↓45
- WearableResting HR 73 bpm
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 44
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Intermediate metabolizerExpected exposure
Microbiome
Shannon diversity 3.2 · butyrate capacity 27/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 52 ms
- Sleep
- 6.2 h
- Steps
- 6,066
- Resting HR
- 73 bpm
Daily log: GI score 59, nutritional resilience 43, adherence 70.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03004 | 50% | S03 | — | — | 56 |
| P-03021 | 47% | S15 | — | — | 57 |
| P-03285 | 44% | S04 | — | — | 54 |
| P-03379 | 44% | S12 | GI-04 | improved | 51 |
| P-03465 | 44% | S17 | CR-01 | improved | 65 |
| P-03201 | 43% | S15 | GI-04 | improved | 68 |
| P-03120 | 42% | S14 | — | — | 61 |
| P-03225 | 42% | S19 | GI-04 | improved | 50 |
| P-03382 | 42% | S01 | GI-04 | improved | 56 |
| P-03280 | 41% | S13 | — | — | 57 |
| P-03463 | 41% | S11 | GI-04 | no change | 55 |
| P-03031 | 37% | S16 | CR-01 | improved | 49 |