Patient P-03341

Synthetic patientONX-7 · Day 142 · 65–74 · M · baseline S14Open companion preview

Therapy response

Stable

Tolerance

Deteriorating

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

96%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 ONX-7 started — Baseline state S14
Day 39 NP-02 recommended — Dietary Support Protocol NP-02
Day 40 Patient accepted — Started NP-02 in the companion
Day 50 GI symptom burden −19% vs expected — Dietary Support Protocol NP-02
Day 56 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 56 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 56.

Primary contributors, last 14 days

Inflammatory activity+19
GI instability+16
Nutritional resilience-9
Toxicity+6
Treatment adherence-3

What helped?

Dietary Support Protocol NP-02Day 39
Result: symptom burden −19%

LIFE OS recommendation

GI Support Protocol GI-04

92%

probability of meaningful tolerance improvement

284 similar trajectories
82% showed improvement
median effect visible after 8 days

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 71 and rising
Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 29/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 66
- WearableHRV 20 ms, trending down
Autonomic recovery ↓45
- WearableResting HR 81 bpm
- WearableShort sleep window
Drug metabolism and exposure ↑20
- BloodToxicity index 53

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Rapid metabolizer
Expected exposure

Microbiome

Shannon diversity 3.2 · butyrate capacity 29/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 20 ms
Sleep: 6.7 h
Steps: 6,021
Resting HR: 79 bpm

Daily log: GI score 71, nutritional resilience 31, adherence 43.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-03049	59%	S14	GI-04	improved	49
P-03390	50%	S14	ME-01	improved	41
P-03030	44%	S14	NP-02	improved	43
P-03037	44%	S14	NP-02	improved	43
P-03323	44%	S14	GI-04	improved	48
P-03345	44%	S14	SC-12	improved	56
P-03081	43%	S10	GI-04	improved	53
P-03460	39%	S11	SC-12	improved	46
P-03413	38%	S14	ME-01	improved	48
P-03430	38%	S14	SC-12	improved	45
P-03251	37%	S14	SC-12	improved	54
P-03003	35%	S08	SC-12	improved	53