Patient P-03341
Therapy response
Stable
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 39 NP-02 recommended — Dietary Support Protocol NP-02
- Day 40 Patient accepted — Started NP-02 in the companion
- Day 50 GI symptom burden −19% vs expected — Dietary Support Protocol NP-02
- Day 56 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 56 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 56.
Primary contributors, last 14 days
- Inflammatory activity+19
- GI instability+16
- Nutritional resilience-9
- Toxicity+6
- Treatment adherence-3
What helped?
- Dietary Support Protocol NP-02Day 39Result: symptom burden −19%
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 82% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log2.6/10
worsening · -0.4 vs previous 14 d
Stress level
Daily log7.8/10
worsening · +0.4 vs previous 14 d
Pessimism score
Daily log6.9/10
worsening · +0.5 vs previous 14 d
Sleep quality
Wearable15.5/100
stable · +0.2 vs previous 14 d
Libido
Daily log1.6/10
worsening · -0.4 vs previous 14 d
HRV
Wearable19.8 ms
worsening · -3.4 vs previous 14 d
Toxicity
Blood53.4/100
worsening · +7.4 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 26 from the failing basin, 74 from restoration.
Would help
- GI-04 GI Support Protocol73% improved among 33 similar · onset 8 d · confidence 97%
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 71%
- SC-12 Supportive Compound89% improved among 9 similar · onset 6 d · confidence 71%
- More proteinGI -6.6 next day on high-intake days · n 28
Would not help
- AD-05 Adherence Supportonly 17% improved among 12 similar
- Keep fat lowGI +6.2 next day on high-intake days · n 17
- Keep histamine lowGI +5.8 next day on high-intake days · n 15
- Keep alcohol lowGI +5.5 next day on high-intake days · n 14
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-6.6supporter · 95%
- Dietary fat load+6.2detractor · 95%
- Histamine load+5.8detractor · 95%
- Alcohol+5.5detractor · 95%
- Lactose+2.7no signal · 43%
- Caffeine-0.4no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 71 and rising
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 29/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 66
- WearableHRV 20 ms, trending down
- Autonomic recovery ↓45
- WearableResting HR 81 bpm
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 53
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 3.2 · butyrate capacity 29/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 20 ms
- Sleep
- 6.7 h
- Steps
- 6,021
- Resting HR
- 79 bpm
Daily log: GI score 71, nutritional resilience 31, adherence 43.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03049 | 59% | S14 | GI-04 | improved | 49 |
| P-03390 | 50% | S14 | ME-01 | improved | 41 |
| P-03293 | 45% | S14 | GI-04 | no change | 41 |
| P-03030 | 44% | S14 | NP-02 | improved | 43 |
| P-03037 | 44% | S14 | NP-02 | improved | 43 |
| P-03323 | 44% | S14 | GI-04 | improved | 48 |
| P-03345 | 44% | S14 | SC-12 | improved | 56 |
| P-03081 | 43% | S10 | GI-04 | improved | 53 |
| P-03460 | 39% | S11 | SC-12 | improved | 46 |
| P-03413 | 38% | S14 | ME-01 | improved | 48 |
| P-03430 | 38% | S14 | SC-12 | improved | 45 |
| P-03251 | 37% | S14 | SC-12 | improved | 54 |