Patient P-03352
Therapy response
Improving
Tolerance
Stable
GI state
Unstable
Inflammatory state
Stable
Nutritional resilience
Unstable
Discontinuation risk
58%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S19
- Day 99 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 99.
Primary contributors, last 14 days
- Treatment adherence-6
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
63%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log3.2/10
worsening · -0.3 vs previous 14 d
Stress level
Daily log7.1/10
stable · -0.1 vs previous 14 d
Pessimism score
Daily log5.6/10
stable · -0.0 vs previous 14 d
Sleep quality
Wearable26.7/100
worsening · -2.1 vs previous 14 d
Libido
Daily log2.9/10
worsening · -0.1 vs previous 14 d
HRV
Wearable38.5 ms
stable · +0.4 vs previous 14 d
Toxicity
Blood52.9/100
improving · -3.4 vs previous 14 d
This trajectory is doing well — what to keep, what to watch
Steering view →Heading towards restoration · 38 from the failing basin, 59 from restoration.
Good elements to keep
- Protein (supports)perturbation · steering +3.7
- Daily walks resumedperturbation · steering +3.3
- Proteinsupporter · GI -2.5 next day
Main detractors to watch
- Low butyrate capacityhidden · steering -17.5
- FUT2 non-secretorhidden · steering -10.6
- Low microbial diversityhidden · steering -7.7
- Bacteroides fragilis elevatedhidden · steering -7.4
- Lactosedetractor · GI +2 next day
- Dietary fat loaddetractor · GI +1.6 next day
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-2.5supporter · 75%
- Lactose+2detractor · 83%
- Dietary fat load+1.6detractor · 62%
- Histamine load+1.6detractor · 62%
- Caffeine-0.6no signal · 19%
- Alcohol+0.4no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 61 and rising
- WearableSleep 6.1 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 33/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 58
- Drug metabolism and exposure ↑55
- DNADPYD *2A → slower clearance
- BloodToxicity index 53
- Autonomic recovery ↓45
- WearableResting HR 79 bpm
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2 · butyrate capacity 33/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 41 ms
- Sleep
- 6.5 h
- Steps
- 3,388
- Resting HR
- 79 bpm
Daily log: GI score 61, nutritional resilience 37, adherence 64.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03444 | 52% | S17 | — | — | 62 |
| P-03260 | 50% | S19 | — | — | 54 |
| P-03271 | 49% | S19 | — | — | 66 |
| P-03267 | 48% | S05 | — | — | 62 |
| P-03164 | 47% | S11 | — | — | 58 |
| P-03191 | 46% | S19 | GI-04 | improved | 51 |
| P-03280 | 45% | S13 | — | — | 57 |
| P-03099 | 44% | S17 | CR-01 | improved | 55 |
| P-03046 | 43% | S20 | GI-04 | no change | 53 |
| P-03166 | 43% | S20 | CR-01 | improved | 62 |
| P-03357 | 43% | S02 | CR-01 | improved | 50 |
| P-03384 | 43% | S01 | — | — | 55 |