Patient P-03376
Therapy response
Unstable
Tolerance
Improving
GI state
Deteriorating
Inflammatory state
Favorable
Nutritional resilience
Favorable
Discontinuation risk
34%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S18
- Day 100 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 100.
Primary contributors, last 14 days
- GI instability+9
- Treatment adherence-7
- Toxicity-6
- Inflammatory activity-2
What helped?
No interventions yet.
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log5.5/10
stable · -0.1 vs previous 14 d
Stress level
Daily log3/10
worsening · +0.4 vs previous 14 d
Pessimism score
Daily log4/10
worsening · +0.4 vs previous 14 d
Sleep quality
Wearable55.3/100
worsening · -3.9 vs previous 14 d
Libido
Daily log5.7/10
stable · -0.1 vs previous 14 d
HRV
Wearable64.2 ms
stable · -2.1 vs previous 14 d
Toxicity
Blood6.1/100
worsening · +1.5 vs previous 14 d
This trajectory is doing well — what to keep, what to watch
Steering view →Heading towards restoration · 53 from the failing basin, 54 from restoration.
Good elements to keep
- Protein (supports)perturbation · steering +9.8
- Butyrate producers intacthidden · steering +7.5
- Daily walks resumedperturbation · steering +3.3
- Proteinsupporter · GI -5.3 next day
Main detractors to watch
- Poor metabolizerhidden · steering -12.7
- Caffeineperturbation · steering -6.5
- Low-HRV stretchperturbation · steering -2.7
- Dietary driftperturbation · steering -2.6
- Caffeinedetractor · GI +4.1 next day
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-5.3supporter · 95%
- Caffeine+4.1detractor · 95%
- Dietary fat load+0.9no signal · 24%
- Lactose-0.7no signal · 17%
- Histamine load+0.4no signal · 15%
- Alcohol+0.1no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Drug metabolism and exposure ↑75
- DNACYP2D6 poor metabolizer → higher exposure
- DNADPYD *2A → slower clearance
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
DNA
Fictional pharmacogenomic panel
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 4.3 · butyrate capacity 71/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 69 ms
- Sleep
- 6.5 h
- Steps
- 4,425
- Resting HR
- 62 bpm
Daily log: GI score 33, nutritional resilience 62, adherence 76.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Keep fibre steady; no new sources this week
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.