Patient P-03376
Immune response 26 at the day-84 endpoint (observed).
Not responding because: poor metabolizer (exposure outside the modelled range); IL6 high-expression variant (inflammatory tone); no butyrate producers (2 keystone absent, butyrate 648 CPM); Escherichia coli above range (LPS load). The drug never had the barrier to work with.
Drift detected on day 41 (trajectory left the model); nothing reported yet — the window to act is open.
3 of 4 scheduled doses in the last 60 days are biologically confirmed (75%). Dose signature: resting HR +5 bpm, HRV −8 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓A 15-minute walk after lunch
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-03376 is on day 146 of ONX-7 (NR, baseline S10): response unstable, tolerance deteriorating, GI deteriorating. Over 14 days response moved +9 and GI +6; discontinuation risk is 25%. The state is between basins, heading towards restoration, after diverging from the model on day 41.
Biology sets the gain: IL6 high-expression variant, Poor metabolizer, Low butyrate capacity; butyrate capacity 26/100, diversity 3.0. Pushing it down: Escherichia coli 14.421% (LPS load) (-38.2), Low butyrate capacity (-34.1), Poor metabolizer (-24.8). Pulling it up: Protein (supports) (+22.6). From the daily log: protein -4.8 GI next day, fat +4.2 GI next day, caffeine +3.8 GI next day.
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 ONX-7 started — Baseline state S10
- Day 41 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 41.
- Nutritional resilience-7
- GI instability+6
- Toxicity+6
- Inflammatory activity-2
- Treatment adherence+2
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards restoration · 64 from the failing basin, 42 from restoration.
- No untried action with strong evidence. Compose one from primitives.
- More proteinGI -4.8 next day on high-intake days · n 22
- AD-05 Adherence Supportonly 38% improved among 8 similar
- Keep fat lowGI +4.2 next day on high-intake days · n 20
- Keep caffeine lowGI +3.8 next day on high-intake days · n 19
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-4.8supporter · 95%
- Dietary fat load+4.2detractor · 95%
- Caffeine+3.8detractor · 95%
- Lactose+1.7no signal · 44%
- Histamine load-1.3no signal · 39%
- Alcohol-0.7no signal · 19%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 2 opportunists above range: Escherichia coli, Klebsiella pneumoniae
- 2 keystone species absent
- Shannon 2.77 (expected ≥ 3)
- 6 resistance genes
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 26/100
- MicrobiomeF. prausnitzii depleted
- Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
- Autonomic recovery ↓40
- Wearable2,896 steps/day
- WearableShort sleep window
- Inflammatory signalling ↓25
- DNAIL6 -174 variant raises baseline inflammatory tone
- Mucosal barrier integrity ↓10
- WearableSleep 5.6 h, below personal baseline
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- MTHFR C677TReduced folate turnover
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
- HRV
- 38 ms
- Sleep
- 5.6 h
- Steps
- 2,923
- Resting HR
- 64 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.