Patient P-03413
Therapy response
Stable
Tolerance
Improving
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 58 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 78 ME-01 recommended — Monitoring Escalation ME-01
- Day 79 Patient accepted — Started ME-01 in the companion
- Day 82 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 58.
Primary contributors, last 14 days
- Treatment adherence+16
- Toxicity-8
- Inflammatory activity-5
- GI instability+3
- Nutritional resilience-2
What helped?
- Monitoring Escalation ME-01Day 78Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
91%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 82% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log1.6/10
worsening · -0.1 vs previous 14 d
Stress level
Daily log6.6/10
stable · -0.3 vs previous 14 d
Pessimism score
Daily log5.7/10
stable · +0.0 vs previous 14 d
Sleep quality
Wearable27.4/100
worsening · -2.6 vs previous 14 d
Libido
Daily log1.9/10
improving · +0.1 vs previous 14 d
HRV
Wearable52.9 ms
stable · +0.4 vs previous 14 d
Toxicity
Blood42.6/100
improving · -2.2 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 28 from the failing basin, 79 from restoration.
Would help
- GI-04 GI Support Protocol73% improved among 33 similar · onset 8 d · confidence 96%
- SC-12 Supportive Compound89% improved among 9 similar · onset 6 d · confidence 70%
- NP-02 Dietary Support Protocol57% improved among 14 similar · onset 10 d · confidence 70%
- More proteinGI -5 next day on high-intake days · n 20
Would not help
- AD-05 Adherence Supportonly 15% improved among 13 similar
- Keep fat lowGI +5.4 next day on high-intake days · n 28
- Keep alcohol lowGI +5.3 next day on high-intake days · n 17
- Keep histamine lowGI +4.3 next day on high-intake days · n 19
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+5.4detractor · 95%
- Alcohol+5.3detractor · 95%
- Protein-5supporter · 95%
- Histamine load+4.3detractor · 95%
- Lactose+3.5detractor · 94%
- Caffeine-0.2no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 78 and rising
- WearableSleep 5.9 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 24/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↓70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 63
- Autonomic recovery ↑45
- WearableResting HR 82 bpm
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 43
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Intermediate metabolizerExpected exposure
Microbiome
Shannon diversity 2.7 · butyrate capacity 24/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 50 ms
- Sleep
- 5.5 h
- Steps
- 5,177
- Resting HR
- 83 bpm
Daily log: GI score 78, nutritional resilience 29, adherence 49.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03105 | 18% | S12 | AD-05 | no change | 60 |
| P-03204 | 18% | S16 | AD-05 | improved | 48 |
| P-03351 | 18% | S07 | AD-05 | no change | 51 |
| P-03034 | 17% | S14 | AD-05 | no change | 30 |
| P-03111 | 17% | S07 | AD-05 | no change | 48 |
| P-03369 | 17% | S18 | AD-05 | no change | 37 |
| P-03424 | 17% | S12 | AD-05 | improved | 41 |
| P-03482 | 17% | S05 | AD-05 | no change | 67 |
| P-03104 | 16% | S14 | AD-05 | no change | 27 |
| P-03122 | 16% | S13 | AD-05 | no change | 40 |
| P-03129 | 16% | S18 | AD-05 | no change | 32 |
| P-03158 | 16% | S17 | AD-05 | no change | 37 |