Patient P-03430
Therapy response
Stable
Tolerance
Improving
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
92%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 39 NP-02 recommended — Dietary Support Protocol NP-02
- Day 40 Patient accepted — Started NP-02 in the companion
- Day 50 No meaningful change — Dietary Support Protocol NP-02
- Day 57 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 59 SC-12 recommended — Supportive Compound SC-12
- Day 60 Patient accepted — Started SC-12 in the companion
- Day 66 GI symptom burden −21% vs expected — Supportive Compound SC-12
- Day 72 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 57.
Primary contributors, last 14 days
- Toxicity-16
- Treatment adherence-12
- Inflammatory activity+4
- Nutritional resilience-4
- GI instability+3
What helped?
- Dietary Support Protocol NP-02Day 39Result: no meaningful change
- Supportive Compound SC-12Day 59Result: symptom burden −21%
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 61 and rising
- WearableSleep 5.7 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 26/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 59
- Autonomic recovery ↑45
- WearableResting HR 77 bpm
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.1 · butyrate capacity 26/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 45 ms
- Sleep
- 6.2 h
- Steps
- 6,150
- Resting HR
- 77 bpm
Daily log: GI score 61, nutritional resilience 39, adherence 42.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03037 | 49% | S14 | NP-02 | improved | 43 |
| P-03123 | 47% | S14 | GI-04 | improved | 50 |
| P-03049 | 46% | S14 | GI-04 | improved | 49 |
| P-03070 | 44% | S14 | GI-04 | improved | 51 |
| P-03090 | 44% | S02 | GI-04 | improved | 48 |
| P-03323 | 44% | S14 | GI-04 | improved | 48 |
| P-03460 | 42% | S11 | SC-12 | improved | 46 |
| P-03251 | 41% | S14 | SC-12 | improved | 54 |
| P-03146 | 40% | S14 | GI-04 | improved | 53 |
| P-03226 | 38% | S05 | GI-04 | improved | 43 |
| P-03341 | 38% | S14 | NP-02 | improved | 49 |
| P-03003 | 37% | S08 | SC-12 | improved | 53 |